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Figure 5 | BMC Developmental Biology

Figure 5

From: Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogastercell lines

Figure 5

Sequence alignments of three common EcR cofactors with their human homologs. A. Subsection of Twister protein sequence contains a highly conserved extended LXD domain (highlighted orange) and a region of what may be an evolving LXD domain (red box). B. Kismet also contains two completely conserved LXD motifs (highlighted yellow). C. Moira and its human homolog SMARCC2 which is part of the well know steroid receptor cofactor complex SWI/SNF show presence of both LXD and extended LXD motifs. Both genes have been shown to be involved in both activation and repression of developmental target genes.

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BMC Developmental Biology

ISSN: 1471-213X

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