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Figure 8 | BMC Developmental Biology

Figure 8

From: Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

Figure 8

wts mutant overgrowth is independent of aPKC signaling. Larval eye discs (A-D) with ey-FLP induced mutant clones (green, or magenta in the merges) and dorsal views of adult mosaic flies (E, F). Grayscale is CycE (A, C) and DIAP1 (B, D). A white bar indicates the location of the MF. (A-F) Expression of wtsRNAi in eye disc clones results in upregulation of CycE (A) and DIAP1 (B) posterior to the MF (example clones highlighted with arrows), resulting in adult flies eclosing with overgrown eyes (E). Coexpression of aPKCCAAXDN with wtsRNAi does not prevent upregulation of CycE (C) and DIAP1 (D) in mutant clones (example clones highlighted with arrows), and adult flies still eclose with overgrown eyes (F).

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BMC Developmental Biology

ISSN: 1471-213X

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