Figure 3
From: Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β?
Kidney size is reduced at early postnatal timepoints in Irs2 -/- mice. Kidneys (n = 3) from (A) 5 d and (B) 25 d wild-type and Irs2-/- male and female mice were removed upon sacrifice and photographed as described. Size in mm is shown for scale. (C) Left kidney-to-body weight ratios were calculated for Irs2+/+ (open squares), Irs2+/- (filled squares) and Irs2-/- (filled triangles) mice at 5 d, 12 d and 25 d male and female mice combined and expressed as g/kg. Data were plotted as mean +/- SEM, n = 3-5 for each group. Statistical significance was determined using one-way ANOVA and Tukey-Kramer multiple comparison test, * p < 0.05, ** p < 0.01, *** p < 0.001.