Figure 3
From: Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects
Spry1;Wnt1-Cre embryos exhibit cleft palate. (A, B) The developing mandible and tongue were removed from E14.5 embryos to show the developing medial epithelial seam of the palatal shelves in WT but not in Spry1;Wnt1-Cre (Spry1) embryos (dash line indicated), (C-H) cross sections of E16.5 embryo heads stained with hematoxylin and eosin. (C, D) Low magnification shows the fused palate and the separated nasopharynx and oral cavity in WT control, but not in Spry1;Wnt1-Cre embryos (from original 10 ×), (E, F) high magnification from the boxed areas in C and D (from original 10 ×), (G, H) high magnification from the boxed areas of E and F (from original 20 ×). OC: oral cavity; PS: palatal shelves; T: tongue. Data are representative of four litters analyzed as this stage.