Table 2 Comparison of Plzf-/- and Plzf7t/7tskeletal phenotypes
From: An allele separating skeletal patterning and spermatogonial renewal functions of PLZF
Structure | Defect | Plzf -/- | Plzf 7t/7t |
|---|---|---|---|
Hindlimb | digit I>II transformation | 92% | 100% |
| Â | preaxial digit resembles digit V or digit I absence | 40% | 20% |
| Â | Talus>calcaneus transformation | 90% | 53% |
| Â | interdigital webbing | 60% | 20% |
| Â | anterior C1 to navicular | 38% | Â |
| Â | C1 to cuboid bone | 42% | Â |
| Â | metatarsal fusion | 15% | 13% |
| Â | metatarsal bony outgrowths | 69% | 40% |
| Â | absent tibia | 98% | Â |
| Â | separation of tibia and fibula | 96% | 47% |
| Â | thickened fibula | 32% | 40% |
| Â | tibia to fibula transformation | 38% | 40% |
| Â | shortened zeugopod/absent fibula | 16% | 33% |
| Â | duplication or absence of patella | 52% | 0% |
| Â | absence of meniscus | 28% | 0% |
Forelimb | preaxial polydactyly | 5% | 0% |
| Â | interdigital webbing | 5% | 0% |
Axial skeletal | 14 thoracic vertebrae | 100% | 0% |
| Â | extra pair of ribs attached to sternum | Â | 73% |
| Â | malformed xiphoid process | 100% | 40% |
| Â | T10 to T11 vertebrae shift | 70% | n/a |
| Â | homeotic transformation of sacral region | 80% | 53% |
| Â | Shortening and kinked tail | 100% | 0% |