Figure 2
From: An allele separating skeletal patterning and spermatogonial renewal functions of PLZF
Limb and axial skeleton phenotypes of the 7t mutant. Panels on the left are wild type, and panels on the right are mutants. (A) Digits I-V are anterior to posterior, respectively. (B) Representative example of a Plzf7t/7thindlimb in which digit III has been duplicated (asterisk). (C) Wild-type has one calcaneus. (D) The tatus of the Plzf7t/7tis homeotically transformed into a calcaneus. The blue triangle indicates a metatarsal fusion of digits I and II. In contrast to the wild-type hindlimbs (E), the mutants (F) display a thinner tibia that appears to be homeotically transformed into a thicker fibula-like structure. The green arrow indicates a failure of the two bones to fuse. (G, H) A dorsal view shows that the total number of thoracic vertebrae are the same in both genotypes. However, whereas the wild type has seven ribs attached to the sternum (I), Plzf7t/7tmutants have up to 10 (J). "Clav" = clavicle.