From: Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice
 | Measurements | |||
---|---|---|---|---|
Landmarks | +/P253R (n = 10) | +/+ littermate (n = 4) | +/S252W (n = 7) | +/+ littermate (n = 11) |
Skull length (rnsla -- rocc)1 | 9.29 mma | 9.77 mm | 9.42 mm* a | 9.83 mm |
Skull height (lpto-bas)1 | 4.78a | 4.65 | 4.91a | 4.70 |
Neurocranial width at squamosal bone (lpsq-rpsq)1 | 6.31 | 6.34 | 6.51* | 6.46 |
Intercanthal distance (lflac-rflac)1 | 3.67a | 3.85 | 3.83a | 3.95 |
Facial width at zygomatic process of temporal bone (lzyt-rzyt)1 | 5.81 | 6.00 | 6.04a | 6.11 |
Maxilla length (laalf-lptyp)1 ** | 4.27a | 4.73 | 4.24a | 4.81 |
Mandible length (mlsin-mlang)1 | 4.31a | 4.53 | 4.47a | 4.69 |
Maxilla/mandible ratio | 0.99 | 1.04 | 0.95 | 1.03 |
Palate length (laalf-lpns)1 ** | 3.36a | 3.48 | 3.24a | 3.50 |
Length of nasal region (lnsla-lflac)*** | 2.50a | 2.79 | 2.64a | 2.74 |
Overall cranial base length (amsph-bas) | 3.09a | 3.19 | 3.25 | 3.28 |
Anterior cranial base length*** (amsph-lsyn) | 1.60a | 1.68 | 1.68 | 1.69 |
Posterior cranial base length (lsyn-bas) | 1.66 | 1.70 | 1.78 | 1.77 |