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Table 1 Skull measurements in Apert syndrome mice and littermate controls

From: Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice

  Measurements
Landmarks +/P253R
(n = 10)
+/+ littermate
(n = 4)
+/S252W (n = 7) +/+ littermate
(n = 11)
Skull length (rnsla -- rocc)1 9.29 mma 9.77 mm 9.42 mm* a 9.83 mm
Skull height (lpto-bas)1 4.78a 4.65 4.91a 4.70
Neurocranial width at squamosal bone (lpsq-rpsq)1 6.31 6.34 6.51* 6.46
Intercanthal distance
(lflac-rflac)1
3.67a 3.85 3.83a 3.95
Facial width at zygomatic process of temporal bone
(lzyt-rzyt)1
5.81 6.00 6.04a 6.11
Maxilla length (laalf-lptyp)1 ** 4.27a 4.73 4.24a 4.81
Mandible length
(mlsin-mlang)1
4.31a 4.53 4.47a 4.69
Maxilla/mandible ratio 0.99 1.04 0.95 1.03
Palate length (laalf-lpns)1 ** 3.36a 3.48 3.24a 3.50
Length of nasal region
(lnsla-lflac)***
2.50a 2.79 2.64a 2.74
Overall cranial base length (amsph-bas) 3.09a 3.19 3.25 3.28
Anterior cranial base length***
(amsph-lsyn)
1.60a 1.68 1.68 1.69
Posterior cranial base length
(lsyn-bas)
1.66 1.70 1.78 1.77
  1. aThe models were significantly different from their control littermates for these linear distances
  2. * Measures come from a sample size of 4.
  3. ** Contrasts between mutants and their control littermates indicated that Fgfr2+/P253Rwere significantly less affected than Fgfr2+/S252W
  4. *** Contrasts between models and their control littermates indicated that Fgfr2+/P253Rwere significantly more affected than Fgfr2+/S252W
  5. 1http://www.getahead.psu.edu for precise landmark definitions.
  6. (Ref. [38] Richtsmeier and Lele, 1993; Ref. [47] Lele and Richtsmeier, 2001)