Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish

Table 1 Upregulated genes classified according to biological process.

BIOLOGICAL PROCESS		Genes differentially expressed detected in this study
Immune system, circulatory	Directed migration	cxcr4, cxcr7, similar to hCXCR6+, scyba+; efnb; slit2; sema3+, sema4*
	Innate immunity	nfkbiaa; *irf5, irf7, irf11; ticam1*
	Hematopoiesis	*klf2, klf3+, klf4, klf10, klf11; ptgs2+, ptgds+, ptgisl+*
Cell adhesion, epithelial integrity		*cdh1, cdh2, cdh4, cdh; itga6, itgb4; cldnb, cldn7*+, cldnh*, ocln*; epcam, pecaml+; f11r*+; cd9+, cd99+**
Morphogenesis		*arx; otx1; otx2; sox9*
Neurogenesis		atoh1, *atoh2+; bdnf; dlx*; msx*; sox21**
DISEASE
Cancer	Metastasis	*mmp2, mmp9, mmp14; c-myb, c-myc; stat3; c-met, gab1, grb10, spint1; amotl2; st14; prss8, adam9, adam23*
DEVELOPMENTAL PATHWAYS	Wnt related	*wnt4, wnt8, wnt10, wnt11, fzd3, fzd4, fzd8, dkk1+, gsk3b, apc, tcf2, gro2, vangl2*
	Nodal/TGFβ-related	*ndr1+, bambi, smad4, oep, foxa1, foxa3, sox17+*
	FGF related	fgf3, *fgf4, fgf8* , *fgf13, fgfr1*
	Hedgehog related	*shh, ptc2*

*described only in ZFIN
+verified by qRT-PCR or in situ hybridization
The table shows a subset of the genes detected in our study that are associated with diverse biological processes. Highlighted in bold are those that have not been shown previously to be expressed in lateral line development. These functions highlight the versatility of the lateral line system for uncovering molecules important for immunity, morphogenesis, neural development and cancer.

ISSN: 1471-213X