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Figure 5 | BMC Developmental Biology

Figure 5

From: Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures

Figure 5

The dorsal midline responds to Shh activation by expanding the Lhx5 - expressing roof plate domain. E9.5 mouse brains were infected with wtShh or ShhN expressing viruses, or pCLE (alkaline phosphatase alone), and harvested at E12.5. Alkaline phosphatase visualization of viral infections (A, F, K) and adjacent section RNA in situ hybridization analysis of the dorsal midline of E12.5 virally infected brains, Gli-1: B, G, L, Gli-2: C, H, M, Ptc-1: D, I, N, Lhx-5 (roof plate): E, J, O. n = 3. Scale bar in A represents 130 μm and all panels in this figure are photographed at the same magnification (5×).

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BMC Developmental Biology

ISSN: 1471-213X

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