Table 1 Immunoreactivity scores for E- and N-cadherin, β-catenin, TTF-1 and caveolin-1 in different types of pulmonary cells in developing human lung during various gestational periods.
From: Epithelial N-cadherin and nuclear β-catenin are up-regulated during early development of human lung
Pseudo-glandular period day 52-week 16 (13 cases) | Canalicular period weeks 16-28 (17 cases) | Saccular period weeks 28-36 (9 cases) | Alveolar period weeks 36-40 (8 cases) | |
|---|---|---|---|---|
E-cadherin | ||||
bronchus | +++ | +++ | +++ | ++ |
bronchiolus | +++ | +++ | +++ | ++ |
alveolus | # + | * + or ++ | # + | # + |
endothelial cell | negative | negative | negative | negative |
stromal cells | negative | negative | negative | negative |
N-cadherin | ||||
bronchus | ++ | ++ | + | (+) |
bronchiolus | + or ++ | ++ | + | (+) |
alveolus | # negative or + | negative | negative | negative |
endothelial cell | negative | negative | negative | negative |
stromal cells | negative | negative | negative | negative |
β-catenin | ||||
bronchus | +++ m | +++ m | +++ m | +++ m |
bronchiolus | +++ m | +++ m | +++ m | +++ m |
alveolus | # +++ n | * +++ n and m | #++ m and (n) | # ++ m and (n) |
endothelial cell | + | + | + | + |
stromal cells | +++ n | + n | negative | negative |
TTF-1 | ||||
bronchus | + | + | + | + |
bronchiolus | ++ | + or ++ | + | + |
alveolus | # +++ | * +++ | # + | # + |
endothelial cell | negative | negative | negative | negative |
stromal cells | negative | negative | negative | negative |
Caveolin-1 | negative | negative | negative | negative |
bronchus | negative | negative | negative | negative |
bronchiolus | negative | negative | +++ | +++ |
alveolus | + | + | + | + |
endothelial cell stromal cells | + | + | + | + |