Fig. 6
From: Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance
Interactions between leading edge subset proteins. A protein-protein interaction (PPI) network for the LES proteins from all significant pathway enrichments was generated in Cytoscape. Proteins in the network are coloured according to pathway cluster from the GSEA, and connections between proteins indicate a protein-protein interaction. Topological analysis was used to identify proteins with a high degree of betweenness centrality (i.e., proteins that connect subnetworks within the interaction diagram). These key proteins are highlighted in yellow. LES proteins with no interactions are not shown in the diagram. The number of LES proteins not shown for each cluster is indicated in parenthesis after the cluster name in the ‘pathway cluster’ key