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  1. Research article

    Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

    Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patte...

    Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G. Seidah and Shoumo Bhattacharya

    BMC Developmental Biology 2017 17:6

    Published on: 26 April 2017

  2. Research article

    Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels

    Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of o...

    Rachael Lumb, Sam Buckberry, Genevieve Secker, David Lawrence and Quenten Schwarz

    BMC Developmental Biology 2017 17:5

    Published on: 13 April 2017

  3. Research article

    Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan

    The molecular mechanisms underlying the development of the unusual echinoderm pentameral body plan and their likeness to mechanisms underlying the development of the bilateral plans of other deuterostomes are ...

    Demian Koop, Paula Cisternas, Valerie B. Morris, Dario Strbenac, Jean Yee Hwa Yang, Gregory A. Wray and Maria Byrne

    BMC Developmental Biology 2017 17:4

    Published on: 13 February 2017

  4. Research article

    A compendium of developmental gene expression in Lake Malawi cichlid fishes

    Lake Malawi cichlids represent one of a growing number of vertebrate models used to uncover the genetic and developmental basis of trait diversity. Rapid evolutionary radiation has resulted in species that sha...

    R. F. Bloomquist, T. E. Fowler, J. B. Sylvester, R. J. Miro and J. T. Streelman

    BMC Developmental Biology 2017 17:3

    Published on: 3 February 2017

  5. Research article

    The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila

    Thus far, a handful of genes have been shown to be related to the wing maturation process in insects. A novel heme peroxidase enzyme known as curly suppressor (Cysu)(formerly CG5873), have been characterized i...

    Dondra Bailey, Mohammed Abul Basar, Sanjay Nag, Nivedita Bondhu, Shaloei Teng and Atanu Duttaroy

    BMC Developmental Biology 2017 17:1

    Published on: 11 January 2017

  6. Research article

    Changes of gonadotropin-releasing hormone receptor 2 during the anadromous spawning migration in Coilia nasus

    An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migr...

    Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu and Da-Peng Li

    BMC Developmental Biology 2016 16:42

    Published on: 24 November 2016

  7. Research article

    Microarray analysis reveals a potential role of LncRNAs expression in cardiac cell proliferation

    Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult...

    Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun and Maoping Chu

    BMC Developmental Biology 2016 16:41

    Published on: 18 November 2016

  8. Research article

    Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis

    Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseas...

    Andrew Robson, Nick D. L. Owens, Susan J. Baserga, Mustafa K. Khokha and John N. Griffin

    BMC Developmental Biology 2016 16:38

    Published on: 26 October 2016

  9. Research article

    Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development

    Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    BMC Developmental Biology 2016 16:37

    Published on: 18 October 2016

  10. Research article

    Lack of effects of ooplasm transfer on early development of interspecies somatic cell nuclear transfer bison embryos

    Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    BMC Developmental Biology 2016 16:36

    Published on: 13 October 2016

  11. Research article

    BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

    Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output ...

    Karen Beets, Michael W. Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M. Chuva de Sousa Lopes, Lieve Umans and An Zwijsen

    BMC Developmental Biology 2016 16:34

    Published on: 10 October 2016

  12. Research article

    Dynamics of nuclear receptor gene expression during Pacific oyster development

    Nuclear receptors are a highly conserved set of ligand binding transcription factors, with essential roles regulating aspects of vertebrate and invertebrate biology alike. Current understanding of nuclear rece...

    Susanne Vogeler, Tim P. Bean, Brett P. Lyons and Tamara S. Galloway

    BMC Developmental Biology 2016 16:33

    Published on: 29 September 2016

  13. Methodology article

    Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles

    Nuclear Factor-Kappa B (NF-kB) is a family of transcription factors that are important in embryonic development, inflammation, epithelial-to-mesenchymal transition and cancer. The 65 kDa RelA subunit is the ma...

    Talha Ijaz, Maki Wakamiya, Hong Sun, Adrian Recinos, Ronald G. Tilton and Allan R. Brasier

    BMC Developmental Biology 2016 16:32

    Published on: 23 September 2016

  14. Research article

    The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis

    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    BMC Developmental Biology 2016 16:31

    Published on: 21 September 2016

  15. Research article

    Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis

    Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian ki...

    Irina I. Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko and Seppo J. Vainio

    BMC Developmental Biology 2016 16:30

    Published on: 31 August 2016

  16. Research article

    Cilia are required for asymmetric nodal induction in the sea urchin embryo

    Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates,...

    Matthias Tisler, Franziska Wetzel, Sabrina Mantino, Stanislav Kremnyov, Thomas Thumberger, Axel Schweickert, Martin Blum and Philipp Vick

    BMC Developmental Biology 2016 16:28

    Published on: 23 August 2016

  17. Research article

    BRG1 interacts with GLI2 and binds Mef2c gene in a hedgehog signalling dependent manner during in vitro cardiomyogenesis

    The Hedgehog (HH) signalling pathway regulates cardiomyogenesis in vivo and in differentiating P19 embryonal carcinoma (EC) cells, a mouse embryonic stem (mES) cell model. To further assess the transcriptional...

    Joel Vincent Fair, Anastassia Voronova, Neven Bosiljcic, Rashida Rajgara, Alexandre Blais and Ilona Sylvia Skerjanc

    BMC Developmental Biology 2016 16:27

    Published on: 2 August 2016

  18. Research article

    Efficient TALEN-mediated myostatin gene editing in goats

    Myostatin (MSTN) encodes a negative regulator of skeletal muscle mass that might have applications for promoting muscle growth in livestock. In this study, we aimed to test whether tar...

    Baoli Yu, Rui Lu, Yuguo Yuan, Ting Zhang, Shaozheng Song, Zhengqiang Qi, Bin Shao, Mengmin Zhu, Fei Mi and Yong Cheng

    BMC Developmental Biology 2016 16:26

    Published on: 27 July 2016

  19. Research article

    Salmonid fish: model organisms to study cardiovascular morphogenesis in conjoined twins?

    There is a gap in knowledge regarding the cardiovascular system in fish conjoined twins, and regarding the cardiovascular morphogenesis of conjoined twins in general. We examined the cardiovascular system in a...

    Per Gunnar Fjelldal, Monica F. Solberg, Tom Hansen, Tone Vågseth, Kevin Alan Glover and Harald Kryvi

    BMC Developmental Biology 2016 16:25

    Published on: 16 July 2016

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