Table 2 Top six pathways generated from IPA for focus genes that are up-regulated in MIINSN oocytes and assigned to their respective gene networks.
From: Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
Pathway | Gene Symbol | Description | Network | Location | Type |
|---|---|---|---|---|---|
Oxidative Phosphorylation | Ndufa1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5 kDa | 1 | Cytoplasm | enzyme |
| Â | Ndufa3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9 kDa | 1 | Cytoplasm | enzyme |
| Â | Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51 kDa | 1 | Cytoplasm | enzyme |
Mitochondrial Dysfunction | Ndufa3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9 kDa | 1 | Cytoplasm | enzyme |
| Â | Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51 kDa | 1 | Cytoplasm | enzyme |
Galactose Metabolism | Glb1 | galactosidase, beta 1 | 1 | Cytoplasm | enzyme |
Oxidative Phosphorylation | Uqcrb | ubiquinol-cytochrome c reductase binding protein | 2 | Cytoplasm | enzyme |
| Â | Uqcrc1 | ubiquinol-cytochrome c reductase core protein I | 2 | Cytoplasm | enzyme |
Protein Ubiquitination | Ubc | ubiquitin C | 2 | Cytoplasm | other |
GABA Receptor Signalling | Ubc | ubiquitin C | 2 | Cytoplasm | other |
Mitochondrial Dysfunction | Uqcrb | ubiquinol-cytochrome c reductase binding protein | 2 | Cytoplasm | enzyme |
| Â | Uqcrc1 | ubiquinol-cytochrome c reductase core protein I | 2 | Cytoplasm | enzyme |
Purine Metabolism | Polr2l | polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa | 2 | Nucleus | enzyme |
Oxidative Phosphorylation | Atp5a1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 4 | Cytoplasm | transporter |
Oxidative Phosphorylation | Atp6v0a1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 4 | Cytoplasm | transporter |
| Â | Atp6v0b | ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit b | 4 | Cytoplasm | transporter |
Protein Ubiquitination | Psmc4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 4 | Nucleus | peptidase |
| Â | Psmc5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 4 | Nucleus | transcription regulator |
| Â | Psmd7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 4 | Cytoplasm | other |
Purine Metabolism | Atf7ip | activating transcription factor 7 interacting protein | 4 | Nucleus | transcription regulator |
| Â | Atp5a1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 4 | Cytoplasm | transporter |
| Â | Atp6v0b | ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit b | 4 | Cytoplasm | transporter |
| Â | Psmc4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 4 | Nucleus | peptidase |
| Â | Psmc5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 4 | Nucleus | transcription regulator |