Table 1 Networks generated from IPA for focus genes that are up-regulated in MIINSN oocytes when compared to MIISN oocytes.*
From: Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
Network | Genes in network | Score | Focus genes | Top functions |
|---|---|---|---|---|
1 | Akt, Anxa2, Bhlhb2, Calpain, Crkl, Glb1, Hoxa7, Insulin, Integrin, Lasp1, Ldl, Mcl1, Mdh2, Mfn2, Nadh2 Dehydrogenase, Nadh2 Dehydrogenase (Ubiquinone), Ndufa1, Ndufa3, Ndufv1, Pdgf Bb, Pi3k, Pik3c3, Pkc(S), Pp2a, Ptpn1, Rac, Rpl27a, Rps6, Rps18, Slc3a2, Smg5, Strn3, Tmsb10, Tsc2, Tspan3 | 42 | 23 | Cancer, Immunological Disease, Tumor Morphology |
2 | Bat3, Bcas3, Calmodulin, Crkrs, Egfr, Helz, Histone H3, Hsp70, Ing1, Invs, Iqgap1 (Includes Eg:8826), Map3k12, Msse, Nbpf15, Nelf, Nr2e1, P38 Mapk, Polr2l (Includes Eg:5441), Prkg1, Ranbp1, Rap1, Rbm16, Rna Polymerase Ii, Setd2, Slc9a8, Smn1, Spag7, Spt1, Tarbp1, Terf2ip, Tgf Beta, Ubc, Uqcrb, Uqcrc1, Wdr36 | 26 | 16 | Post-Translational Modification, Cancer, Genetic Disorder |
3 | Abpa (Includes Eg:11354), Amino Acids, Arrb2, Cebpa, Clta, Cltb, Ddx21, Eef1a2, Farp2, Fntb, Glipr1, Grasp, Grin3b, Grina, H1fx, Ifitm2, Insr, Mark3, Myo6, Nmda Receptor, Nusap1, Paip2, Pfkfb3, Pim1, Prkx, Sag, Snrk, Src, Stk38, Stk17a, Tfam, Tk2, Tp53, Tp53rk, Vegf | 22 | 14 | Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry |
4 | Afg3l2, Arl2, Atf7ip, Atox1, Atp13a2, Atp13a5, Atp5a1, Atp6v0a1, Atp6v0b, Atp6v0e2, Atp6v1c2, Atp6v1d, Atp6v1e2, Atp6v1g2, Atp6v1h, Atpase, Ddx19b, Ddx3y (Includes Eg:26900), Dqx1, Eif3a, Eif3f, Eif3j, Eif4e, Gtp, H+-Transporting Two-Sector Atpase, Lsm10 (Includes Eg:84967), Mlh1, Psmc4, Psmc5, Psmd7, Ralbp1, Rfc4, Rsf1, Spast, Tcirg1 | 22 | 14 | Molecular Transport, Protein Synthesis, Gene Expression |
5 | Acaa2, Acaa1b, Acsl4, Alad, Bcat1, Cidec, Cpt2, Ddx11, Dleu1, Dleu2, Dnmt3l, E2f1, Emp1, Erbb2, Exosc9, Fng, Glg1, Gtf3c2, Hdac1 (Includes Eg:3065), Hn1, Lxn, Mfap1, Mfng, Myc, Notch1, Psat1, Rfng, Rps16, Rps20, Snrpn, Sycp3, Tbp, Tle4, Tmem126a, Uxt | 20 | 13 | Cancer, Dermatological Diseases and Conditions, Cell Cycle |
6 | Aars, Arsb, Arsd, Arse, Arsf, Arsg, Arsi, Arsj, Cct5, Cxcl12, Cxcr6 (Includes Eg:10663), Eif4h, Gns, Golga3, Hsd17b10, Kdelr2, Loxl2, Nsdhl, Pls3, Pth, Rab33b, Rbm14, Rdh11, Sec61a1, Sec61g, Slc34a1, Slc34a2, Srebf1, Ssr2, Stch, Sulf2, Sumf1, Syvn1, Tgfb1, Xbp1 | 20 | 13 | Tissue Development, Tissue Morphology, Cellular Function and Maintenance |
7 | Abtb1, Actin Alpha-Ca2+-Myosin-Tropomyosin-Troponinc-Troponin I-Troponin T, Adcy9, Beta-Estradiol, Ca2+, Clec3b, Cnn3, Fn1, Ifi30, Igf1, Kcnn2, Mek1/2, Myh2, Nmur2, Nudt1, Pcna, Pdlim2, Pfkl, Pkia, Pla2g12a, Pla2g2d, Plg, Poldip2, Psma2, Psmb2, Psmd6, Psmd14, Pten, S100a2, Saps2, Serpinb12, Slc6a9, Spint1, Trpv2, Tsta3 | 18 | 12 | Cancer, Cellular Growth and Proliferation, Reproductive System Disease |
8 | Alp, Aprt, Atp1a3, Atp5l, Bmp2, Chgb, Cox7a1, Creb1, Esd, Fgf7, Fos, Foxm1, Gfra1, Hcg 25371, Hgs, Hr, Klf3, Me1, Myo5b, Nfe2l2, Nkx6-2, Nudt7, Pgd, Phyh, Psmc3ip, Punc, Rxrb, Smarcd2, Tcea3, Thrb, Thyroid Hormone, Trim3, Trip4, Trip11, Ttf1 | 16 | 11 | Gene Expression, Connective Tissue Development and Function, Cellular Development |
9 | Anapc5, Aptx, Cdca5, Cdca7l, Cdkn2a, Ctbp2, Ddx55, Deaf1, Epb42, Gypa, Icos, Ipo13, Ldb1, Lmo2, Lmo4, Mdm4, Nfkbib, Nhlh1, Nr3c1, P1, P4-Di(Adenosine-5') Tetraphosphate, Pdcd2, Pex3, Pex19, Plagl1, Rpl5, Sae1, Skp1, Smad2/3-Smad4, Sod2, Tcf3, Tfap2b, Tfap2c, Tgif1, Ube2i, Zp2 | 14 | 10 | Gene Expression, Cell Cycle, Skeletal and Muscular System Development and Function |
10 | C4bpa, Foxj2 | 2 | 1 | Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Tissue Development |