Figure 4
From: Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
Down-regulation of Oct-4 expression in MIINSN oocytes induces the up-regulation of a group of Oct-4-regulated genes associated with gene expression networks involved in the activation of adverse pathways. (A) Twenty-five Oct-4-regulated genes present in the list of regulated genes determined with our microarray analysis. Twenty-three of them are up-regulated (green square), two are down-regulated (red square). Within each square the name of the gene and the n-fold up- or down-regulation are reported. (B) The two top gene expression networks generated when IPA was interrogated with the list of these 25 Oct-4-regulated genes. Grey symbols are focus genes (use the zoom in tool to enlarge the networks).