Figure 5

Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT₄ antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT₄ antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT₄ antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT₄ antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow)