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Figure 7 | BMC Developmental Biology

Figure 7

From: The first trimester human trophoblast cell line ACH-3P: A novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations – TNF-α stimulates MMP15 expression

Figure 7

Comparison between HLA-G negative and positive trophoblasts as well as HLA-G negative and positive ACH-3P subpopulations. Both HLA-G positive subpopulations express a higher amount of ITGA5, MMP2, MMP9, β-hCG, IGF2R and MMP15 than their syngeneic, HLA-G negative counterpart. The higher β-hCG secretion and IGF2R expression suggest the presence of an autocrine loop stimulating invasion. Furthermore, the strong effect of TNFα on the up-regulation of MMP15 expression in HLA-G positive cells suggests modulation of trophoblast invasion and/or action by TNFα.

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BMC Developmental Biology

ISSN: 1471-213X

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