Figure 8From: Mesenchymally-derived Insulin-like growth factor 1 provides a paracrine stimulus for trophoblast migrationModel showing paracrine influence of IGF-I on the migration of extravillous cytotrophoblast from the distal edge of an anchoring villus. In order to generate a pool of extravillous cells, initial anchorage to the decidual ECM is required. These cells then respond to local stimuli to detach and infiltrate the decidua.Back to article page