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Figure 5 | BMC Developmental Biology

Figure 5

From: Mesenchymally-derived Insulin-like growth factor 1 provides a paracrine stimulus for trophoblast migration

Figure 5

First trimester mesenchymal villous explants cultured in the presence of IGF-I (a, high magnification; b, lower magnification), which produces cell streaming activity. (c) An explant in fibroblast conditioned medium after IGF-1 depletion. Cells in the outgrowth are rounded and clustered together, showing little migratory activity. (d) An explant cultured in IGF-1 and a function-inhibitory monoclonal antibody to the receptor IGF-R1. Migration is inhibited though not completely abolished by the antibody.

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BMC Developmental Biology

ISSN: 1471-213X

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