Figure 4
From: Metabolomic insights into system-wide coordination of vertebrate metamorphosis
Significant abundance changes of the metabolites in the urea cycle, arginine and purine/pyrimidine metabolism pathway. (A) Overall abundance changes of the metabolites. Black circles indicate a significant (padj < 0.001) abundance change at at least one developmental stage range during metamorphosis. Grey circles indicate a nonsignificant abundance change, and white circles indicate the metabolites were not detected. (B) Progression of the abundance change of the metabolites relative to the premetamorphic stage (TK VI–X). The abundance levels of each metabolite at other TK stage ranges were compared to the abundance level at the premetamorphic stage (αadj = 0.05). The metabolites are depicted as follows: significant ↑ (red); significant ↓ (blue); nonsignificant change (grey); and not observed (white).