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Figure 6 | BMC Developmental Biology

Figure 6

From: Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

Figure 6

aPKC signaling is required for the impaired Hippo pathway signaling in scrib mutants. Larval eye/antennal discs with ey-FLP induced mutant clones marked by GFP expression (green, or magenta in the merges). Grayscale is β-GAL. A white bar indicates the location of the MF. (A-D) Coexpression of aPKCCAAXDN and bskDN in clones does not alter ex-lacZ (A) or fj-lacZ (C) expression, but when aPKCCAAXDN and bskDN are coexpressed in scrib1 clones, the normal pattern of ex-lacZ (B) and fj-lacZ (D) expression is restored (compared with scrib1 clones expressing bskDN alone in Figure 1).

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BMC Developmental Biology

ISSN: 1471-213X

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