Figure 5
From: The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development
Loss of S1P 1 R inhibits cardiac growth and morphology at E10.5. E10.5 embryos were fixed, sectioned saggitally and stained with H&E. (A) S1P1R+/+ hearts exhibits normal morphology. (B) S1P1R-/- hearts demonstrate reduced myocardial tissue with a thin ventricular wall. (C) The average area of the myocardium at the level of the cardiac cushion, as well as the average area of the atrioventricular (AV) canal cushions and outflow tract (OFT) cushions, were determined. V = ventricle. S1P1R+/+, N = 4; S1P1R+/-, N = 5; S1P1R-/-, N = 3, *P ≤ 0.02. Scale bar equals 500 μm.