Figure 8
From: Mtmr8 is essential for vasculature development in zebrafish embryos
A hypothesized signal pathway that Mtmr8 regulates artery specification and hematovascular progenitor specification in zebrafish embryo. Mtmr8 inhibits PI3K/Akt pathway, and activates Hh and Vegf signaling pathway, which may interact with each other in regulating vasculature development. The pink arrows indicate the regulatory loop.