Figure 6From: Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flowA model explaining the control of Ablim1 expression in the node and the left LPM. (a) Nodal flow and Pkd2 activate both the Nodal, Pitx2 pathway and a second pathway "X". Both pathways in turn activate Ablim1 in the left LPM. (b) In the node, the initial change of Ablim1 expression, from low level pan-nodal to a perinodal ring, require nodal flow and Pkd2 activity. Subsequent L-R asymmetry of perinodal ring expression may be controlled by nodal flow and its interaction with the remodelling of the node during development.Back to article page