Figure 5
From: β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis
Cyclin D1 is essential for skull and suture development. (A-D) Skeletal staining of P0 mice reveals calvarial ossification defects associated with inactivation of cyclin D1 (CycD1+/+; A, C and CycD1-/-; B, D). Enlargements of insets in A and B are shown in panels C and D. (E, F) The loss of cyclin D1 affects ossification of the bone plate analyzed by von Kossa staining. Arrows indicate the osteogenic fronts of CycD1+/+ (E) and CycD1-/- (F). Scale bars, 2 mm (A, B); 1 mm (C, D); 100 μm (E, F).