Figure 4
From: PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity
The PLCγ site of TrkB is involved in the maturation of nerve fibers. (A-D) Cross sections of P100 nerves to the posterior cristae of TrkbPLC/PLC and aged matched control mice are shown. (E-F) TEM images from P100 nerves to the posterior cristae; note that TrkbPLC/PLC mice show similar number of nerve fibers compared to the control animals, but nerve fibers tend to be much smaller in diameter with less myelin. Left brace "{" indicates the thickness of myelin in E-F panels and shows that reduction varies between fibers of comparable diameter of the neuronal process. Scale bars, 100 μm in A-D, 1 μm in E, F.