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  1. Content type: Research article

    Two stages of genome activation have been identified in the mouse embryo. Specifically, minor transcriptional activation is evident at the one-cell stage and a second major episode of activation occurs at the ...

    Authors: Reza K Oqani, Hong R Kim, Yun F Diao, Chang S Park and Dong I Jin

    Citation: BMC Developmental Biology 2011 11:33

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  2. Content type: Research article

    The Drosophila wing represents a particularly appropriate model to investigate the developmental control of phenotypic variation. Previous studies which aimed to identify candidate genes for wing morphology demon...

    Authors: Valeria P Carreira, Ignacio M Soto, Julián Mensch and Juan J Fanara

    Citation: BMC Developmental Biology 2011 11:32

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  3. Content type: Research article

    The metamorphosis of the spionid polychaete Pseudopolydora vexillosa includes spontaneous settlement onto soft-bottom habitats and morphogenesis that can be completed in a very short time. A previous study on the...

    Authors: Kondethimmanahalli H Chandramouli, Flora SY Mok, Hao Wang and Pei-Yuan Qian

    Citation: BMC Developmental Biology 2011 11:31

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  4. Content type: Research article

    The transition from fertilized egg to embryo is accompanied by a multitude of changes in gene expression, and the transcriptional events that underlie these processes have not yet been fully characterized. In ...

    Authors: Liselotte Vesterlund, Hong Jiao, Per Unneberg, Outi Hovatta and Juha Kere

    Citation: BMC Developmental Biology 2011 11:30

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  5. Content type: Research article

    Consistent asymmetry of the left-right (LR) axis is a crucial aspect of vertebrate embryogenesis. Asymmetric gene expression of the TGFβ superfamily member Nodal related 1 (Nr1) in the left lateral mesoderm plate...

    Authors: Katia Carneiro, Claudia Donnet, Tomas Rejtar, Barry L Karger, Gustavo A Barisone, Elva Díaz, Sandhya Kortagere, Joan M Lemire and Michael Levin

    Citation: BMC Developmental Biology 2011 11:29

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  6. Content type: Research article

    The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like...

    Authors: Philipp Dussmann, Judith I Pagel, Sabina Vogel, Terese Magnusson, Rene Zimmermann, Ernst Wagner, Wolfgang Schaper, Manfred Ogris and Elisabeth Deindl

    Citation: BMC Developmental Biology 2011 11:28

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  7. Content type: Research article

    Neurogenesis control and the prevention of premature differentiation in the vertebrate embryo are crucial processes, allowing the formation of late-born cell types and ensuring the correct shape and cytoarchit...

    Authors: Katharine J Webb, Marion Coolen, Christian J Gloeckner, Christian Stigloher, Brigitte Bahn, Stefanie Topp, Marius Ueffing and Laure Bally-Cuif

    Citation: BMC Developmental Biology 2011 11:27

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  8. Content type: Research article

    The embryonic organizer (i.e., Spemann organizer) has a pivotal role in the establishment of the dorsoventral (DV) axis through the coordination of BMP signaling. However, as impaired organizer function also r...

    Authors: Máté Varga, Shingo Maegawa and Eric S Weinberg

    Citation: BMC Developmental Biology 2011 11:26

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  9. Content type: Research article

    Oocyte-derived maternal RNAs drive early embryogenesis when the newly formed embryo is transcriptionally inactive. Recent studies in zebrafish have identified the role of microRNAs during the maternal-to-embry...

    Authors: Swamy K Tripurani, Kyung-Bon Lee, Gabbine Wee, George W Smith and Jianbo Yao

    Citation: BMC Developmental Biology 2011 11:25

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  10. Content type: Research article

    Peroxisomes are organelles whose roles in fatty acid metabolism and reactive oxygen species elimination have contributed much attention in understanding their origin and biogenesis. Many studies have shown that d...

    Authors: Mark A Fox, Logan A Walsh, Michelle Nieuwesteeg and Sashko Damjanovski

    Citation: BMC Developmental Biology 2011 11:24

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  11. Content type: Research article

    Bryozoans represent a large lophotrochozoan phylum with controversially discussed phylogenetic position and in group relationships. Developmental processes during the budding of bryozoans are in need for revis...

    Authors: Thomas Schwaha and Timothy S Wood

    Citation: BMC Developmental Biology 2011 11:23

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  12. Content type: Research article

    Lipid rafts enriched in glycosphingolipids (GSLs), cholesterol and signaling molecules play an essential role not only for signal transduction started by ligand binding, but for intracellular events such as or...

    Authors: Ban Sato, Yohko U Katagiri, Kenji Miyado, Nozomu Okino, Makoto Ito, Hidenori Akutsu, Hajime Okita, Akihiro Umezawa, Junichiro Fujimoto, Kiyotaka Toshimori and Nobutaka Kiyokawa

    Citation: BMC Developmental Biology 2011 11:22

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  13. Content type: Research article

    FGF signalling regulates numerous aspects of early embryo development. During gastrulation in amniotes, epiblast cells undergo an epithelial to mesenchymal transition (EMT) in the primitive streak to form the ...

    Authors: Katharine M Hardy, Tatiana A Yatskievych, JH Konieczka, Alexander S Bobbs and Parker B Antin

    Citation: BMC Developmental Biology 2011 11:20

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  14. Content type: Research article

    The gene transformer-2, which is involved in sex determination, has been studied in Drosophila, Musca, Ceratitis, Anastrepha and Lucilia. All these members of Diptera belong to the suborder Brachycera. In this wo...

    Authors: Iker Martín, María F Ruiz and Lucas Sánchez

    Citation: BMC Developmental Biology 2011 11:19

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  15. Content type: Research article

    Mitogen-activated protein kinase (MAPK) cascades (p38, JNK, ERK pathways) are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their...

    Authors: Emmanuèle Mouchel-Vielh, Julien Rougeot, Martine Decoville and Frédérique Peronnet

    Citation: BMC Developmental Biology 2011 11:17

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  16. Content type: Research article

    Endothelial-specific knockout of the transcription factor serum response factor (SRF) results in embryonic lethality by mid-gestation. The associated phenotype exhibits vascular failure in embryos as well as v...

    Authors: Mary L Holtz and Ravi P Misra

    Citation: BMC Developmental Biology 2011 11:18

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  17. Content type: Research article

    Studies on artificial hybridization of different Anguilla species were conducted recently, i.e. female A. australis with male A. dieffenbachii, and female A. japonica with male A. anguilla. The existence of these...

    Authors: Erik Burgerhout, Sebastiaan A Brittijn, Tagried Kurwie, Paul Decker, Ron P Dirks, Arjan P Palstra, Herman P Spaink and Guido EEJM Van den Thillart

    Citation: BMC Developmental Biology 2011 11:16

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  18. Content type: Research article

    The production of nephrons suddenly ends in mice shortly after birth when the remaining cells of the multi-potent progenitor mesenchyme begin to differentiate into nephrons. We exploited this terminal wave of ...

    Authors: Eric W Brunskill, Hsiao L Lai, D Curtis Jamison, S Steven Potter and Larry T Patterson

    Citation: BMC Developmental Biology 2011 11:15

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  19. Content type: Research article

    We developed an efficient in vitro method to differentiate mouse ES cells into the definitive endoderm (DE) and then Pdx1-expressing pancreatic lineages using mesodermal-derived supporting cells, M15. Using this ...

    Authors: Soichiro Ogaki, Seiko Harada, Nobuaki Shiraki, Kazuhiko Kume and Shoen Kume

    Citation: BMC Developmental Biology 2011 11:13

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  20. Content type: Research article

    Epigenetic reprogramming is critical for genome regulation during germ line development. Genome-wide demethylation in mouse primordial germ cells (PGC) is a unique reprogramming event essential for erasing epi...

    Authors: Sara MW Hyldig, Nicola Croxall, David A Contreras, Preben D Thomsen and Ramiro Alberio

    Citation: BMC Developmental Biology 2011 11:11

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  21. Content type: Research article

    The signaling cascades that direct the morphological differentiation of the vascular system during early embryogenesis are not well defined. Several signaling pathways, including Notch and VEGF signaling, are ...

    Authors: Jessica N Copeland, Yi Feng, Naveen K Neradugomma, Patrick E Fields and Jay L Vivian

    Citation: BMC Developmental Biology 2011 11:12

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  22. Content type: Research article

    The transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified by phosphorylation. We have generated mouse mutan...

    Authors: Daniel Silberschmidt, Alina Rodriguez-Mallon, Prathiba Mithboakar, Gaetano Calì, Elena Amendola, Remo Sanges, Mariastella Zannini, Marzia Scarfò, Pasquale De Luca, Lucio Nitsch, Roberto Di Lauro and Mario De Felice

    Citation: BMC Developmental Biology 2011 11:9

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    The Erratum to this article has been published in BMC Developmental Biology 2016 16:29

  23. Content type: Research article

    The C. elegans sperm protein SPE-42, a membrane protein of unknown structure and molecular function, is required for fertilization. Sperm from worms with spe-42 mutations appear normal but are unable to fertilize...

    Authors: Luke D Wilson, Jacqueline M Sackett, Bryce D Mieczkowski, Abigail L Richie, Kara Thoemke, Jon N Rumbley and Tim L Kroft

    Citation: BMC Developmental Biology 2011 11:10

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  24. Content type: Methodology article

    Although the transcriptome of minute quantities of cells can be profiled using nucleic acid amplification techniques, it remains difficult to distinguish between active and stored messenger RNA. Transcript sto...

    Authors: Sara Scantland, Jean-Philippe Grenon, Marie-Hélène Desrochers, Marc-André Sirard, Edward W Khandjian and Claude Robert

    Citation: BMC Developmental Biology 2011 11:8

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  25. Content type: Research article

    Vitamin A (VA) has a key role in vertebrate morphogenesis, determining body patterning and growth through the control of cell proliferation and differentiation processes. VA regulates primary molecular pathway...

    Authors: Ignacio Fernández, Maria Darias, Karl B Andree, David Mazurais, Jose Luís Zambonino-Infante and Enric Gisbert

    Citation: BMC Developmental Biology 2011 11:7

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  26. Content type: Research article

    The skeletal elements of vertebrate embryonic limbs are prefigured by rod- and spot-like condensations of precartilage mesenchymal cells. The formation of these condensations depends on cell-matrix and cell-ce...

    Authors: Ramray Bhat, Kenneth M Lerea, Hong Peng, Herbert Kaltner, Hans-Joachim Gabius and Stuart A Newman

    Citation: BMC Developmental Biology 2011 11:6

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  27. Content type: Research article

    The three distinct types of kidneys, pronephros, mesonephros and metanephros, develop consecutively in vertebrates. The earliest form of embryonic kidney, the pronephros, is derived from intermediate mesoderm ...

    Authors: Christiane Drews, Sabine Senkel and Gerhart U Ryffel

    Citation: BMC Developmental Biology 2011 11:5

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  28. Content type: Research article

    The plastic monomer and plasticizer bisphenol A (BPA), used for manufacturing polycarbonate plastic and epoxy resins, is produced at over 2.5 million metric tons per year. Concerns have been raised that BPA ac...

    Authors: Yann Gibert, Sana Sassi-Messai, Jean-Baptiste Fini, Laure Bernard, Daniel Zalko, Jean-Pierre Cravedi, Patrick Balaguer, Monika Andersson-Lendahl, Barbara Demeneix and Vincent Laudet

    Citation: BMC Developmental Biology 2011 11:4

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  29. Content type: Research article

    Appropriate transcriptional regulation is required for cone photoreceptor development and integrity. To date, only a few cis-regulatory elements that control cone photoreceptor-specific expression have been chara...

    Authors: Maria E Morrissey, Sara Shelton, Susan E Brockerhoff, James B Hurley and Breandán N Kennedy

    Citation: BMC Developmental Biology 2011 11:3

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  30. Content type: Research article

    Cdk8 is a component of the mediator complex which facilitates transcription by RNA polymerase II and has been shown to play an important role in development of Dictyostelium discoideum. This eukaryote feeds as si...

    Authors: David M Greene, Gareth Bloomfield, Jason Skelton, Alasdair Ivens and Catherine J Pears

    Citation: BMC Developmental Biology 2011 11:2

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  31. Content type: Methodology article

    Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggres...

    Authors: Jørn R Henriksen, Bjørn Helge Haug, Jochen Buechner, Ellen Tømte, Cecilie Løkke, Trond Flaegstad and Christer Einvik

    Citation: BMC Developmental Biology 2011 11:1

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  32. Content type: Research article

    Mammary glands harbor a profound burden of apoptotic cells (ACs) during post-lactational involution, but little is known regarding mechanisms by which ACs are cleared from the mammary gland, or consequences if...

    Authors: Melissa Sandahl, Debra M Hunter, Karen E Strunk, H Shelton Earp and Rebecca S Cook

    Citation: BMC Developmental Biology 2010 10:122

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  33. Content type: Methodology article

    Understanding the dynamic cellular behaviors and underlying molecular mechanisms that drive morphogenesis is an ongoing challenge in biology. Live imaging provides the necessary methodology to unravel the syne...

    Authors: Anna Ferrer-Vaquer, Anna Piliszek, Guangnan Tian, Robert J Aho, Daniel Dufort and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2010 10:121

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  34. Content type: Research article

    Development of the posterior lateral line (PLL) system in zebrafish involves cell migration, proliferation and differentiation of mechanosensory cells. The PLL forms when cranial placodal cells delaminate and ...

    Authors: Viviana E Gallardo, Jin Liang, Martine Behra, Abdel Elkahloun, Eduardo J Villablanca, Vincenzo Russo, Miguel L Allende and Shawn M Burgess

    Citation: BMC Developmental Biology 2010 10:120

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  35. Content type: Research article

    The rostral telencephalic dorsal midline is an organizing center critical for the formation of the future cortex and hippocampus. While the intersection of WNTs, BMPs, and FGFs establishes boundaries within th...

    Authors: Diana S Himmelstein, Chunming Bi, Brian S Clark, Brian Bai and Jhumku D Kohtz

    Citation: BMC Developmental Biology 2010 10:118

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  36. Content type: Research article

    The proper balance of cell division and cell death is of crucial importance for all kinds of developmental processes and for maintaining tissue homeostasis in mature tissues. Dysregulation of this balance ofte...

    Authors: Vladimir S Mashanov, Olga R Zueva, Carmencita Rojas-Catagena and Jose E Garcia-Arraras

    Citation: BMC Developmental Biology 2010 10:117

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  37. Content type: Research article

    Mouse genetic study has demonstrated that Axin2 is essential for calvarial development and disease. Haploid deficiency of β-catenin alleviates the calvarial phenotype caused by Axin2 deficiency. This loss-of-f...

    Authors: Anthony J Mirando, Takamitsu Maruyama, Jiang Fu, Hsiao-Man Ivy Yu and Wei Hsu

    Citation: BMC Developmental Biology 2010 10:116

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  38. Content type: Research article

    Protogenin (Prtg) has been identified as a gene which is highly expressed in the mouse mandible at embryonic day 10.5 (E10.5) by a cDNA subtraction method between mandibles at E10.5 and E12.0. Prtg is a new membe...

    Authors: Keiko F Takahashi, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Ming Xie, Haruyoshi Yamaza, Hiroaki Fujiwara, Yukiko Ookuma, Kengo Nagata, Hiroko Wada, Takako Sakai, Yoshihiro Terada and Hidetaka Sakai

    Citation: BMC Developmental Biology 2010 10:115

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  39. Content type: Research article

    Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycol...

    Authors: Chien-Tsun Kuan, Jinli Chang, Jan-Eric Mansson, Jianjun Li, Charles Pegram, Pam Fredman, Roger E McLendon and Darell D Bigner

    Citation: BMC Developmental Biology 2010 10:114

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  40. Content type: Research article

    Initiation of the hair follicle placode and its subsequent growth, maturation and cycling in post-natal skin requires signaling interactions between epithelial cells and adjacent dermal cells and involves Shh ...

    Authors: Mindy C DeRouen, Hanson Zhen, Si Hui Tan, Samantha Williams, M Peter Marinkovich and Anthony E Oro

    Citation: BMC Developmental Biology 2010 10:112

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  41. Content type: Research article

    Fatty acids are precursors in the synthesis of surfactant phospholipids. Recently, we showed expression of apolipoprotein C-II (apoC-II), the essential cofactor of lipoprotein lipase (LPL), in the fetal mouse ...

    Authors: Mélissa Côté, Pierre R Provost, Marie-Christine Gérard-Hudon and Yves Tremblay

    Citation: BMC Developmental Biology 2010 10:111

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  42. Content type: Methodology article

    KillerRed (KR) is a novel photosensitizer that efficiently generates reactive oxygen species (ROS) in KR-expressing cells upon intense green or white light illumination in vitro, resulting in damage to their plas...

    Authors: Cathleen Teh, Dmitry M Chudakov, Kar-Lai Poon, Ilgar Z Mamedov, Jun-Yan Sek, Konstantin Shidlovsky, Sergey Lukyanov and Vladimir Korzh

    Citation: BMC Developmental Biology 2010 10:110

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  43. Content type: Research article

    Attenuation of the EGFR (Epidermal Growth Factor Receptor) signalling cascade is crucial to control cell fate during development. A candidate-based RNAi approach in C. elegans identified CDT-2 as an attenuator of...

    Authors: Gino B Poulin and Julie Ahringer

    Citation: BMC Developmental Biology 2010 10:109

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  44. Content type: Research article

    Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellu...

    Authors: Mark C van Turnhout, Henk Schipper, Barend van Lagen, Han Zuilhof, Sander Kranenbarg and Johan L van Leeuwen

    Citation: BMC Developmental Biology 2010 10:108

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  45. Content type: Research article

    The Notch signaling pathway regulates a diverse array of developmental processes, and aberrant Notch signaling can lead to diseases, including cancer. To obtain a more comprehensive understanding of the geneti...

    Authors: Philippos Mourikis, Robert J Lake, Christopher B Firnhaber and Brian S DeDecker

    Citation: BMC Developmental Biology 2010 10:107

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  46. Content type: Database

    We have developed genetic methods in zebrafish by using the Tol2 transposable element; namely, transgenesis, gene trapping, enhancer trapping and the Gal4FF-UAS system. Gene trap constructs contain a splice accep...

    Authors: Koichi Kawakami, Gembu Abe, Tokuko Asada, Kazuhide Asakawa, Ryuichi Fukuda, Aki Ito, Pradeep Lal, Naoko Mouri, Akira Muto, Maximilliano L Suster, Hitomi Takakubo, Akihiro Urasaki, Hironori Wada and Mikio Yoshida

    Citation: BMC Developmental Biology 2010 10:105

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