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  1. Mtss1 encodes an actin-binding protein, dysregulated in a variety of tumors, that interacts with sonic hedgehog/Gli signaling in epidermal cells. Given the prime importance of this pathway for cerebellar devel...

    Authors: Alexander Glassmann, Sabine Molly, Lachezar Surchev, Tommy A Nazwar, Martin Holst, Wolfgang Hartmann, Stephan L Baader, John Oberdick, Torsten Pietsch and Karl Schilling
    Citation: BMC Developmental Biology 2007 7:111
  2. In recent years, considerable knowledge has been gained on the molecular mechanisms underlying retinal cell fate specification. However, hitherto studies focused primarily on the six major retinal cell classes...

    Authors: Jean-Philippe Dullin, Morgane Locker, Mélodie Robach, Kristine A Henningfeld, Karine Parain, Solomon Afelik, Tomas Pieler and Muriel Perron
    Citation: BMC Developmental Biology 2007 7:110
  3. Postnatal muscle growth is largely depending on the number and size of muscle fibers. The number of myofibers and to a large extent their metabolic and contractile properties, which also influence their size, ...

    Authors: Eduard Muráni, Mária Murániová, Siriluck Ponsuksili, Karl Schellander and Klaus Wimmers
    Citation: BMC Developmental Biology 2007 7:109
  4. A sensitive, ubiquitously expressed tetracycline inducible system would be a valuable tool in mouse transgenesis. However, this has been difficult to obtain due to position effects observed at different chromo...

    Authors: Eleni Z Katsantoni, Nora E Anghelescu, Robbert Rottier, Matthijs Moerland, Michael Antoniou, Rini de Crom, Frank Grosveld and John Strouboulis
    Citation: BMC Developmental Biology 2007 7:108
  5. Blastomere injection of mRNA or antisense oligonucleotides has proven effective in analyzing early gene function in Xenopus. However, functional analysis of genes involved in neuronal differentiation and axon pat...

    Authors: Julien Falk, Jovana Drinjakovic, Kin Mei Leung, Asha Dwivedy, Aoife G Regan, Michael Piper and Christine E Holt
    Citation: BMC Developmental Biology 2007 7:107
  6. The organization of the different tissues of an animal requires mechanisms that regulate cell-cell adhesion to promote and maintain the physical separation of adjacent cell populations. In the Drosophila imaginal...

    Authors: Eugenia Villa-Cuesta, Esther González-Pérez and Juan Modolell
    Citation: BMC Developmental Biology 2007 7:106
  7. The Neuregulin family of ligands and their receptors, the Erbb tyrosine kinases, have important roles in epidermal and mammary gland development as well as during carcinogenesis. Previously, we demonstrated th...

    Authors: Heena Panchal, Olivia Wansbury, Suzanne Parry, Alan Ashworth and Beatrice Howard
    Citation: BMC Developmental Biology 2007 7:105
  8. Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransfera...

    Authors: Sophie La Salle, Christopher C Oakes, Oana R Neaga, Déborah Bourc'his, Timothy H Bestor and Jacquetta M Trasler
    Citation: BMC Developmental Biology 2007 7:104
  9. The neural retina is a highly structured tissue of the central nervous system that is formed by seven different cell types that are arranged in layers. Despite much effort, the genetic mechanisms that underlie...

    Authors: Cristina Garcia-Frigola, Maria Isabel Carreres, Celia Vegar and Eloisa Herrera
    Citation: BMC Developmental Biology 2007 7:103
  10. Based on inhibition tests, the alpha6beta1 integrin was suggested to be a sperm receptor, but further experiments using gene deletion techniques have shown that neither oocyte alpha6, nor beta1 integrin subuni...

    Authors: Virginie Barraud-Lange, Nathalie Naud-Barriant, Line Saffar, Liliane Gattegno, Beatrice Ducot, Anne-Sophie Drillet, Morgane Bomsel, Jean-Philippe Wolf and Ahmed Ziyyat
    Citation: BMC Developmental Biology 2007 7:102
  11. Heterorhabditis bacteriophora is applied throughout the world for the biological control of insects and is an animal model to study interspecies interactions, e.g. mutualism, parasitism and vector-borne disease.

    Authors: Todd A Ciche and Paul W Sternberg
    Citation: BMC Developmental Biology 2007 7:101
  12. Comparative genomics is currently one of the most popular approaches to study the regulatory architecture of vertebrate genomes. Fish-mammal genomic comparisons have proved powerful in identifying conserved no...

    Authors: Adam Woolfe, Debbie K Goode, Julie Cooke, Heather Callaway, Sarah Smith, Phil Snell, Gayle K McEwen and Greg Elgar
    Citation: BMC Developmental Biology 2007 7:100
  13. Dmrt1 is a highly conserved gene involved in the determination and early differentiation phase of the primordial gonad in vertebrates. In the fish medaka dmrt1bY, a functional duplicate of the autosomal dmrt1a ge...

    Authors: Amaury Herpin, Detlev Schindler, Anita Kraiss, Ute Hornung, Christoph Winkler and Manfred Schartl
    Citation: BMC Developmental Biology 2007 7:99
  14. Although originally identified as embryonic axon guidance cues, semaphorins are now known to regulate multiple, distinct, processes crucial for neuronal network formation including axon growth and branching, d...

    Authors: R Jeroen Pasterkamp, Sharon M Kolk, Anita JCGM Hellemons and Alex L Kolodkin
    Citation: BMC Developmental Biology 2007 7:98
  15. GATA-2 is a transcription factor required for hematopoietic stem cell survival as well as for neuronal development in vertebrates. It has been shown that specific expression of GATA-2 in blood progenitor cells re...

    Authors: Zhongan Yang, Hong Jiang, Fang Zhao, Deepa B Shankar, Kathleen M Sakamoto, Michael Q Zhang and Shuo Lin
    Citation: BMC Developmental Biology 2007 7:97
  16. Reciprocal interactions between two extra-embryonic tissues, the extra-embryonic ectoderm and the visceral endoderm, and the pluripotent epiblast, are required for the establishment of anterior-posterior polar...

    Authors: Aitana Perea-Gomez, Sigolène M Meilhac, Karolina Piotrowska-Nitsche, Dionne Gray, Jérôme Collignon and Magdalena Zernicka-Goetz
    Citation: BMC Developmental Biology 2007 7:96
  17. The muscle fiber number and fiber composition of muscle is largely determined during prenatal development. In order to discover genes that are involved in determining adult muscle phenotypes, we studied the ge...

    Authors: Sigrid A Lehnert, Antonio Reverter, Keren A Byrne, Yonghong Wang, Greg S Nattrass, Nicholas J Hudson and Paul L Greenwood
    Citation: BMC Developmental Biology 2007 7:95
  18. Thyroid hormones (THs) are vital in the maintenance of homeostasis and in the control of development. One postembryonic developmental process that is principally regulated by THs is amphibian metamorphosis. Th...

    Authors: Dominik Domanski and Caren C Helbing
    Citation: BMC Developmental Biology 2007 7:94
  19. Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase, is known to play roles in many biological processes. Two closely related GSK3 isoforms encoded by distinct genes: GSK3α (51 kDa) and...

    Authors: Huang-Chieh Lee, Jen-Ning Tsai, Pei-Yin Liao, Wei-Yuan Tsai, Kai-Yen Lin, Chung-Cheng Chuang, Chi-Kuang Sun, Wen-Chang Chang and Huai-Jen Tsai
    Citation: BMC Developmental Biology 2007 7:93
  20. The embryonic definitive endoderm (DE) gives rise to organs of the gastrointestinal and respiratory tract including the liver, pancreas and epithelia of the lung and colon. Understanding how DE progenitor cell...

    Authors: Juan Hou, Anita M Charters, Sam C Lee, Yongjun Zhao, Mona K Wu, Steven JM Jones, Marco A Marra and Pamela A Hoodless
    Citation: BMC Developmental Biology 2007 7:92
  21. Chick definitive endoderm is an important source of signals that pattern the early embryo forming a central structure around which the body plan is constructed. Although the origin of definitive endoderm has b...

    Authors: Susan C Chapman, Kiyoshi Matsumoto, Qin Cai and Gary C Schoenwolf
    Citation: BMC Developmental Biology 2007 7:91
  22. Oocyte developmental competence is highly affected by the phase of ovarian follicular wave. Previous studies have shown that oocytes from subordinate follicles recovered at growth phase (day 3 after estrus) ar...

    Authors: Nasser Ghanem, Michael Hölker, Franca Rings, Danyel Jennen, Ernst Tholen, Marc-André Sirard, Helmut Torner, Wilhelm Kanitz, Karl Schellander and Dawit Tesfaye
    Citation: BMC Developmental Biology 2007 7:90
  23. The intermediate filament Nestin has been reported as a marker for stem cells and specific precursor cell populations in the developing mammalian central nervous system (CNS). Nestin expressing precursors may ...

    Authors: Julia Mahler and Wolfgang Driever
    Citation: BMC Developmental Biology 2007 7:89
  24. lin-4 and let-7, the two founding members of heterochronic microRNA genes, are firstly confirmed in Caenorhabditis elegans to control the proper timing of developmental programs in a heterochronic pathway. let-7 ...

    Authors: Shiping Liu, Qingyou Xia, Ping Zhao, Tingcai Cheng, Kaili Hong and Zhonghuai Xiang
    Citation: BMC Developmental Biology 2007 7:88
  25. Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment id...

    Authors: Curtis R French, Timothy Erickson, Davon Callander, Karyn M Berry, Ron Koss, Daniel W Hagey, Jennifer Stout, Katrin Wuennenberg-Stapleton, John Ngai, Cecilia B Moens and Andrew J Waskiewicz
    Citation: BMC Developmental Biology 2007 7:85
  26. Alternative promoters usage is an important paradigm in transcriptional control of mammalian gene expression. However, despite the growing interest in alternative promoters and their role in genome diversifica...

    Authors: Amir Pozner, Joseph Lotem, Cuiying Xiao, Dalia Goldenberg, Ori Brenner, Varda Negreanu, Ditsa Levanon and Yoram Groner
    Citation: BMC Developmental Biology 2007 7:84
  27. The vertebrate adult axial skeleton, trunk and limb skeletal muscles and dermis of the back all arise from early embryonic structures called somites. Somites are symmetrically positioned flanking the embryo ax...

    Authors: Caroline J Sheeba, Isabel Palmeirim and Raquel P Andrade
    Citation: BMC Developmental Biology 2007 7:83
  28. Programmed cell death is used to remove excess cells between ommatidia in the Drosophila pupal retina. This death is required to establish the crystalline, hexagonal packing of ommatidia that characterizes the ad...

    Authors: Jeffrey M Copeland, Ian Bosdet, J Douglas Freeman, Ming Guo, Sharon M Gorski and Bruce A Hay
    Citation: BMC Developmental Biology 2007 7:82
  29. The Kit gene encodes a receptor tyrosine kinase involved in various biological processes including melanogenesis, hematopoiesis and gametogenesis in mice and human. A large number of Kit mutants has been describe...

    Authors: Laetitia Magnol, Marie-Clémence Chevallier, Valérie Nalesso, Stéphanie Retif, Helmut Fuchs, Martina Klempt, Patricia Pereira, Michel Riottot, Sandra Andrzejewski, Bich-Thuy Doan, Jean-Jacques Panthier, Anne Puech, Jean-Claude Beloeil, Martin Hrabe de Angelis and Yann Hérault
    Citation: BMC Developmental Biology 2007 7:81
  30. Three types of cell lines have been established from mouse blastocysts: embryonic stem (ES) cells, trophoblast stem (TS) cells, and extra-embryonic endoderm (XEN) cells, which have the potential to differentia...

    Authors: Daisuke Shimosato, Makoto Shiki and Hitoshi Niwa
    Citation: BMC Developmental Biology 2007 7:80
  31. Hematopoietic development in vertebrate embryos results from the sequential contribution of two pools of precursors independently generated. While intra-embryonic precursors harbour the features of hematopoiet...

    Authors: Sébastien JD Giroux, Celmar Alves-Leiva, Yann Lécluse, Patrick Martin, Olivier Albagli and Isabelle Godin
    Citation: BMC Developmental Biology 2007 7:79
  32. In the CNS, several P2 receptors for extracellular nucleotides are identified on neurons and glial cells to participate to neuron-neuron, glia-glia and glia-neuron communication.

    Authors: Susanna Amadio, Fabrizio Vacca, Alessandro Martorana, Giuseppe Sancesario and Cinzia Volonté
    Citation: BMC Developmental Biology 2007 7:77
  33. The midgut undergoes histolysis and remodeling during the larval to adult transition in holometabolous insects, but the molecular mechanisms underlying this process are not well understood.

    Authors: Jia-Lin Wang, Xiao-Juan Jiang, Qian Wang, Li-Jing Hou, Da-Wei Xu, Jin-Xing Wang and Xiao-Fan Zhao
    Citation: BMC Developmental Biology 2007 7:76
  34. Little is known about the control of the development of vertebrate unpaired appendages such as the caudal fin, one of the key morphological specializations of fishes. Recent analysis of lamprey and dogshark me...

    Authors: Yavor Hadzhiev, Zsolt Lele, Simone Schindler, Stephen W Wilson, Per Ahlberg, Uwe Strähle and Ferenc Müller
    Citation: BMC Developmental Biology 2007 7:75
  35. Protein Kinase D (PKD) is an effector of diacylglycerol-regulated signaling pathways. Three isoforms are known in mammals that have been linked to diverse cellular functions including regulation of cell prolif...

    Authors: Dieter Maier, Anja C Nagel, Helena Gloc, Angelika Hausser, Sabrina J Kugler, Irmgard Wech and Anette Preiss
    Citation: BMC Developmental Biology 2007 7:74
  36. Larval molting and metamorphosis are important physiological processes in the life cycle of the holometabolous insect. We used suppression subtractive hybridization (SSH) to identify genes differentially expre...

    Authors: Du-Juan Dong, Hong-Juan He, Lian-Qin Chai, Xiao-Juan Jiang, Jin-Xing Wang and Xiao-Fan Zhao
    Citation: BMC Developmental Biology 2007 7:73
  37. At fertilisation, mammalian oocytes are activated by oscillations of intracellular Ca2+ ([Ca2+]i). Phospholipase Cζ, which is introduced by fertilising spermatozoon, triggers [Ca2+]i oscillations through the gene...

    Authors: Agnieszka Jędrusik, Anna Ajduk, Paweł Pomorski and Marek Maleszewski
    Citation: BMC Developmental Biology 2007 7:72
  38. Flatfish metamorphosis is a thyroid hormone (TH) driven process which leads to a dramatic change from a symmetrical larva to an asymmetrical juvenile. The effect of THs on muscle and in particular muscle sarco...

    Authors: Marco A Campinho, Nádia Silva, Mari A Nowell, Lynda Llewellyn, Glen E Sweeney and Deborah M Power
    Citation: BMC Developmental Biology 2007 7:71
  39. In honeybees, differential feeding of female larvae promotes the occurrence of two different phenotypes, a queen and a worker, from identical genotypes, through incremental alterations, which affect general gr...

    Authors: Angel R Barchuk, Alexandre S Cristino, Robert Kucharski, Luciano F Costa, Zilá LP Simões and Ryszard Maleszka
    Citation: BMC Developmental Biology 2007 7:70
  40. Thymic epithelial cells (TECs) promote thymocyte maturation and are required for the early stages of thymocyte development and for positive selection. However, investigation of the mechanisms by which TECs per...

    Authors: Julie Gordon, Shiyun Xiao, Bernard Hughes III, Dong-ming Su, Samuel P Navarre, Brian G Condie and Nancy R Manley
    Citation: BMC Developmental Biology 2007 7:69
  41. Expression of the mouse Delta-like 1 (Dll1) gene in the presomitic mesoderm and in the caudal halves of somites of the developing embryo is required for the formation of epithelial somites and for the maintenance...

    Authors: Ingeborg Teppner, Sonja Becker, Martin Hrabé de Angelis, Achim Gossler and Johannes Beckers
    Citation: BMC Developmental Biology 2007 7:68
  42. Ovarian folliculogenesis in mammals is a complex process involving interactions between germ and somatic cells. Carefully orchestrated expression of transcription factors, cell adhesion molecules and growth fa...

    Authors: Saurabh Joshi, Holly Davies, Lauren Porter Sims, Shawn E Levy and Jurrien Dean
    Citation: BMC Developmental Biology 2007 7:67
  43. Combining microarray results and biological pathway information will add insight into biological processes. Pathway information is widely available in databases through the internet.

    Authors: Marinus FW te Pas, Ina Hulsegge, Albart Coster, Marco H Pool, Henri H Heuven and Luc LG Janss
    Citation: BMC Developmental Biology 2007 7:66
  44. Fibre type specification is a poorly understood process beginning in embryogenesis in which skeletal muscle myotubes switch myosin-type to establish fast, slow and mixed fibre muscle groups with distinct funct...

    Authors: Deborah Merrick, Tao Ting, Lukas Kurt Josef Stadler and Janet Smith
    Citation: BMC Developmental Biology 2007 7:65
  45. Normal preimplantation embryo development encompasses a series of events including first cleavage division, activation of the embryonic genome, compaction and blastocyst formation.

    Authors: Karen Goossens, Ann Van Soom, Mario Van Poucke, Leen Vandaele, Jo Vandesompele, Alex Van Zeveren and Luc J Peelman
    Citation: BMC Developmental Biology 2007 7:64
  46. Genetic studies have shown that formation of pancreatic endocrine cells in mice is dependent on the cell autonomous action of the bHLH transcription factor Neurogenin3 and that the extent and timing of endocri...

    Authors: Jonas Ahnfelt-Rønne, Jacob Hald, Anne Bødker, Hani Yassin, Palle Serup and Jacob Hecksher-Sørensen
    Citation: BMC Developmental Biology 2007 7:63