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Stem cell biology and cellular reprogramming

Section edited by Xiuchun (Cindy) Tian

The Stem cell biology and cellular reprogramming section considers manuscripts in basic and applied research on stem cell biology including but not limited to: derivation, propagation, pluripotency, differentiation and cellular reprogramming of embryonic, tissue-specific, and induce pluripotent stem cells. 

  1. Sonic hedgehog (Shh) is an important signalling protein involved in the induction of early cartilaginous differentiation. Herein, we demonstrate that Shh markedly induces chondrogenesis of rabbit bone marrow s...

    Authors: Liyang Chen, Gejun Liu, Wenjun Li and Xing Wu

    Citation: BMC Developmental Biology 2019 19:18

    Content type: Research article

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  2. The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a norm...

    Authors: Peter J. O’Shaughnessy, Rod T. Mitchell, Ana Monteiro, Laura O’Hara, Lyndsey Cruickshanks, Hedi Claahsen-van der Grinten, Pamela Brown, Margaret Abel and Lee B. Smith

    Citation: BMC Developmental Biology 2019 19:8

    Content type: Research article

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  1. The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical rol...

    Authors: Michael Reimer Jr, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan and Sridhar Rao

    Citation: BMC Developmental Biology 2019 19:16

    Content type: Research article

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  2. In this work we have determined molecular signatures of oviduct epithelial and progenitor cells. We have proposed a panel of selected marker genes, which correspond with the phenotype of oviduct cells of a lay...

    Authors: Katarzyna Stadnicka, Anna Sławińska, Aleksandra Dunisławska, Bertrand Pain and Marek Bednarczyk

    Citation: BMC Developmental Biology 2018 18:9

    Content type: Research article

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  3. Nuclear Factor-Kappa B (NF-kB) is a family of transcription factors that are important in embryonic development, inflammation, epithelial-to-mesenchymal transition and cancer. The 65 kDa RelA subunit is the ma...

    Authors: Talha Ijaz, Maki Wakamiya, Hong Sun, Adrian Recinos III, Ronald G. Tilton and Allan R. Brasier

    Citation: BMC Developmental Biology 2016 16:32

    Content type: Methodology article

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  4. Myostatin (MSTN) encodes a negative regulator of skeletal muscle mass that might have applications for promoting muscle growth in livestock. In this study, we aimed to test whether tar...

    Authors: Baoli Yu, Rui Lu, Yuguo Yuan, Ting Zhang, Shaozheng Song, Zhengqiang Qi, Bin Shao, Mengmin Zhu, Fei Mi and Yong Cheng

    Citation: BMC Developmental Biology 2016 16:26

    Content type: Research article

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  5. It has been suggested that the ectopic expression of PDX1, a dominant pancreatic transcription factor, plays a critical role in the developmental programming of the pancreas even from cells of unrelated tissue...

    Authors: Shruti Balaji, Yu Zhou, Anasuya Ganguly, Emmanuel C. Opara and Shay Soker

    Citation: BMC Developmental Biology 2016 16:8

    Content type: Research article

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  6. Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; ...

    Authors: Dongjie Zhou, Xinghui Shen, Yanli Gu, Na Zhang, Tong Li, Xi Wu and Lei Lei

    Citation: BMC Developmental Biology 2014 14:28

    Content type: Research article

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  7. Bone marrow derived mesenchymal stem cells (bmMSCs) are multipotent cells that can differentiate into diverse cell types, including cardiomyocytes. BmMSC-based transplantation is capable of repairing acute and...

    Authors: Junfang Wu, Jie Niu, Xiaopeng Li, Xianwei Wang, Zhikun Guo and Fenxi Zhang

    Citation: BMC Developmental Biology 2014 14:21

    Content type: Research article

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  8. The formation of a tubular organ, such as the heart, requires the communication of positional and polarity signals between migratory cells. Key to this process is the establishment of a new luminal domain on t...

    Authors: Jessica Vanderploeg, L Lourdes Vazquez Paz, Allison MacMullin and J Roger Jacobs

    Citation: BMC Developmental Biology 2012 12:8

    Content type: Research article

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  9. Multipotent stem cells have been successfully isolated from various tissues and are currently utilized for tissue-engineering and cell-based therapies. Among the many sources, skin has recently emerged as an a...

    Authors: Radhakrishnan Vishnubalaji, Muthurangan Manikandan, May Al-Nbaheen, Balamuthu Kadalmani, Abdullah Aldahmash and Nehad M Alajez

    Citation: BMC Developmental Biology 2012 12:7

    Content type: Research article

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  10. Hemangioblasts are known as the common precursors for primitive hematopoietic and endothelial lineages. Their existence has been supported mainly by the observation that both cell types develop in close proxim...

    Authors: Vera Teixeira, Natacha Arede, Rui Gardner, Joaquín Rodríguez-León and Ana T Tavares

    Citation: BMC Developmental Biology 2011 11:76

    Content type: Methodology article

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  11. During Drosophila development, titers of the steroid ecdysone trigger and maintain temporal and tissue specific biological transitions. Decades of evidence reveal that the ecdysone response is both unique to spec...

    Authors: Melissa B Davis, Inigo SanGil, Grace Berry, Rashidat Olayokun and Lori H Neves

    Citation: BMC Developmental Biology 2011 11:66

    Content type: Research article

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  12. The T-box transcription factor TBX3 is necessary for early embryonic development and for the normal development of the mammary gland. Homozygous mutations, in mice, are embryonic lethal while heterozygous muta...

    Authors: Jing Liu, Taraneh Esmailpour, Xiying Shang, Gultekin Gulsen, Andy Liu and Taosheng Huang

    Citation: BMC Developmental Biology 2011 11:65

    Content type: Research article

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  13. Surgical removal of the lens from larval Xenopus laevis results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arisin...

    Authors: Robert C Day and Caroline W Beck

    Citation: BMC Developmental Biology 2011 11:54

    Content type: Research article

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  14. In vitro studies using the myogenic cell line C2C12 demonstrate that bone morphogenetic protein-2 (BMP-2) converts the developmental pathway of C2C12 from a myogenic cell lineage to an osteoblastic cell lineag...

    Authors: Kayoko Aoyama, Akira Yamane, Takeo Suga, Erika Suzuki, Tadayoshi Fukui and Yoshiki Nakamura

    Citation: BMC Developmental Biology 2011 11:44

    Content type: Research article

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