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Regeneration and repair

Section edited by Enrique Amaya

This section considers all molecular and cellular processes involved in tissue and whole organism regeneration and repair, including but not limited to tissue differentiation and pathogenesis of human diseases, modelling regeneration in Planarians and salamander, the anatomical and functional integration of new tissue or cells in plants and animals.

  1. Content type: Research article

    All animals have mechanisms for healing damage to the epithelial sheets that cover the body and line internal cavities. Epithelial wounds heal either by cells crawling over the wound gap, by contraction of a s...

    Authors: Zach Kamran, Katie Zellner, Harry Kyriazes, Christine M. Kraus, Jean-Baptiste Reynier and Jocelyn E. Malamy

    Citation: BMC Developmental Biology 2017 17:17

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  2. Content type: Research article

    Flatworms possess pluripotent stem cells that can give rise to all cell types, which allows them to restore lost body parts after injury or amputation. This makes flatworms excellent model systems for studying...

    Authors: Birgit Lengerer, Elise Hennebert, Patrick Flammang, Willi Salvenmoser and Peter Ladurner

    Citation: BMC Developmental Biology 2016 16:20

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  3. Content type: Research article

    We previously reported that the pluripotent stem cells can differentiate into cardiomyocytes (CMs) by co-culture with neonatal CMs (NCMs) in vitro. However, the involving mechanism is not clear.

    Authors: Dongbo Ou, Qi Wang, Yanjin Huang, Di Zeng, Ting Wei, Lu Ding, Xiaoli Li, Qiangsun Zheng and Yan Jin

    Citation: BMC Developmental Biology 2016 16:11

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  4. Content type: Research article

    Akt (PKB) is a serine threonine protein kinase downstream of the phosphoinositide 3-kinase (PI3K) pathway. In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation,...

    Authors: T. Harshani Peiris, Daniel Ramirez, Paul G. Barghouth and Néstor J. Oviedo

    Citation: BMC Developmental Biology 2016 16:7

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  5. Content type: Methodology article

    Time-lapse imaging has proven highly valuable for studying development, yielding data of much finer resolution than traditional “still-shot” studies and allowing direct examination of tissue and cell dynamics....

    Authors: Eduardo E. Zattara, Kate W. Turlington and Alexandra E. Bely

    Citation: BMC Developmental Biology 2016 16:6

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  6. Content type: Research article

    Microenvironments called niches maintain resident stem cell populations by balancing self-renewal with differentiation, but the genetic regulation of this process is unclear. The niche of the Drosophila testis...

    Authors: Amanda J. Monahan and Michelle Starz-Gaiano

    Citation: BMC Developmental Biology 2016 16:5

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  7. Content type: Research article

    Salamanders regenerate their tails after amputation anywhere along their length. How the system faithfully reconstitutes the original number of segments and length is not yet known.

    Authors: Carr D. Vincent, Fabian Rost, Wouter Masselink, Lutz Brusch and Elly M. Tanaka

    Citation: BMC Developmental Biology 2015 15:48

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  8. Content type: Research article

    The endogenous ability to dedifferentiate, re-pattern, and re-differentiate adult cells to repair or replace damaged or missing structures is exclusive to only a few tetrapod species. The Mexican axolotl is on...

    Authors: Catherine D. McCusker, Antony Athippozhy, Carlos Diaz-Castillo, Charless Fowlkes, David M. Gardiner and S. Randal Voss

    Citation: BMC Developmental Biology 2015 15:45

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  9. Content type: Research article

    Acute kidney injury in mammals, which is caused by cardiovascular diseases or the administration of antibiotics with nephrotoxic side-effects is a life-threatening disease, since loss of nephrons is irreversib...

    Authors: Beate Hoppe, Stefan Pietsch, Martin Franke, Sven Engel, Marco Groth, Matthias Platzer and Christoph Englert

    Citation: BMC Developmental Biology 2015 15:43

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  10. Content type: Research article

    Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors ...

    Authors: Mariana G Simões, Anabela Bensimon-Brito, Mariana Fonseca, Ana Farinho, Fábio Valério, Sara Sousa, Nuno Afonso, Anoop Kumar and Antonio Jacinto

    Citation: BMC Developmental Biology 2014 14:49

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  11. Content type: Methodology article

    Efforts to elucidate the cellular and molecular mechanisms of regeneration have required the application of methods to detect specific cell types and tissues in a growing cohort of experimental animal models. ...

    Authors: David J Forsthoefel, Forrest A Waters and Phillip A Newmark

    Citation: BMC Developmental Biology 2014 14:45

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  12. Content type: Research article

    The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that ma...

    Authors: Kentaro Hirose, Taishi Shiomi, Shunya Hozumi and Yutaka Kikuchi

    Citation: BMC Developmental Biology 2014 14:42

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  13. Content type: Research article

    To gain insight into what differences might restrict the capacity for limb regeneration in Xenopus froglets, we used High Performance Liquid Chromatography (HPLC)/double mass spectrometry to characterize protein ...

    Authors: Nandini Rao, Fengyu Song, Deepali Jhamb, Mu Wang, Derek J Milner, Nathaniel M Price, Teri L Belecky-Adams, Mathew J Palakal, Jo Ann Cameron, Bingbing Li, Xiaoping Chen and David L Stocum

    Citation: BMC Developmental Biology 2014 14:32

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  14. Content type: Methodology article

    Tissue injury has been employed to study diverse biological processes such as regeneration and inflammation. In addition to physical or surgical based methods for tissue injury, current protocols for localized...

    Authors: José Moya-Díaz, Oscar A Peña, Mario Sánchez, Daniela A Ureta, Nicole G Reynaert, Consuelo Anguita-Salinas, Gonzalo Marín and Miguel L Allende

    Citation: BMC Developmental Biology 2014 14:7

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  15. Content type: Research article

    After completion of embryogenesis, many organisms experience an additional obligatory developmental transition to attain a substantially different juvenile or adult form. During anuran metamorphosis, the aquat...

    Authors: Taka-Aki Ichu, Jun Han, Christoph H Borchers, Mary Lesperance and Caren C Helbing

    Citation: BMC Developmental Biology 2014 14:5

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  16. Content type: Research article

    Human amniotic fluid cells (hAFCs) may differentiate into multiple cell lineages and thus have a great potential to become a donor cell source for regenerative medicine. The ability of hAFCs to differentiate i...

    Authors: Dongmei Lai, Fangyuan Wang, Yifei Chen, Li Wang, Yanlin Wang and Weiwei Cheng

    Citation: BMC Developmental Biology 2013 13:34

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  17. Content type: Methodology article

    Molecular studies of appendage regeneration have been hindered by the lack of a stable and efficient means of transferring exogenous genes. We therefore sought an efficient integrating virus system that could ...

    Authors: Shahryar Khattak, Tatiana Sandoval-Guzmán, Nicole Stanke, Stephanie Protze, Elly M Tanaka and Dirk Lindemann

    Citation: BMC Developmental Biology 2013 13:17

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  18. Content type: Methodology article

    The freshwater planarian Schmidtea mediterranea has emerged as a powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in situ hybridization (WISH) and whole-mount fluorescent

    Authors: Ryan S King and Phillip A Newmark

    Citation: BMC Developmental Biology 2013 13:8

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  19. Content type: Research article

    The contribution of cell proliferation to regeneration varies greatly between different metazoan models. Planarians rely on pluripotent neoblasts and amphibian limb regeneration depends upon formation of a pro...

    Authors: Yale J Passamaneck and Mark Q Martindale

    Citation: BMC Developmental Biology 2012 12:34

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  20. Content type: Research article

    Zebrafish has emerged as a powerful model organism to study the process of regeneration. This teleost fish has the ability to regenerate various tissues and organs like the heart, spinal cord, retina and fins....

    Authors: Ana Sofia Azevedo, Sara Sousa, António Jacinto and Leonor Saúde

    Citation: BMC Developmental Biology 2012 12:24

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  21. Content type: Research article

    Mammals are not able to restore lost appendages, while many amphibians are. One important question about epimorphic regeneration is related to the origin of the new tissues and whether they come from mature ce...

    Authors: Alexandre Miguel Cavaco Rodrigues, Bea Christen, Mercé Martí and Juan Carlos Izpisúa Belmonte

    Citation: BMC Developmental Biology 2012 12:9

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  22. Content type: Research article

    The molecular mechanisms governing vertebrate appendage regeneration remain poorly understood. Uncovering these mechanisms may lead to novel therapies aimed at alleviating human disfigurement and visible loss ...

    Authors: Nick R Love, Yaoyao Chen, Boyan Bonev, Michael J Gilchrist, Lynne Fairclough, Robert Lea, Timothy J Mohun, Roberto Paredes, Leo AH Zeef and Enrique Amaya

    Citation: BMC Developmental Biology 2011 11:70

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  23. Content type: Research article

    The freshwater planarian Schmidtea mediterranea exhibits two distinct reproductive modes. Individuals of the sexual strain are cross-fertilizing hermaphrodites with reproductive organs that develop post-embryonic...

    Authors: Tracy Chong, Joel M Stary, Yuying Wang and Phillip A Newmark

    Citation: BMC Developmental Biology 2011 11:69

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  24. Content type: Research article

    Determining the type and source of cells involved in regenerative processes has been one of the most important goals of researchers in the field of regeneration biology. We have previously used several cellula...

    Authors: José E García-Arrarás, Griselle Valentín-Tirado, Jaime E Flores, Rey J Rosa, Angélica Rivera-Cruz, José E San Miguel-Ruiz and Karen Tossas

    Citation: BMC Developmental Biology 2011 11:61

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  25. Content type: Research article

    Understanding the mechanisms governing cell fate specification remains one of the main challenges in the study of retinal development. In this context, molecular markers that identify specific cell types becom...

    Authors: Christian Gutierrez, Minda McNally and M Valeria Canto-Soler

    Citation: BMC Developmental Biology 2011 11:46

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  26. Content type: Research article

    The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like...

    Authors: Philipp Dussmann, Judith I Pagel, Sabina Vogel, Terese Magnusson, Rene Zimmermann, Ernst Wagner, Wolfgang Schaper, Manfred Ogris and Elisabeth Deindl

    Citation: BMC Developmental Biology 2011 11:28

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