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Organogenesis

This section considers studies in the development of organs and tissues.

Page 1 of 2

  1. Content type: Research article

    Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ec...

    Authors: Naomi Shinotsuka, Yoshifumi Yamaguchi, Kenichi Nakazato, Yudai Matsumoto, Atsushi Mochizuki and Masayuki Miura

    Citation: BMC Developmental Biology 2018 18:17

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  2. Content type: Research article

    The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Differe...

    Authors: Leonie Lichtenstein, Kornelia Grübel and Johannes Spaethe

    Citation: BMC Developmental Biology 2018 18:1

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  3. Content type: Research article

    The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However,...

    Authors: Linda Sharp, Thomas Pratt, Gillian E. MacKay, Margaret A. Keighren, Jean H. Flockhart, Emma J. Chandler, David J. Price, John O. Mason and John D. West

    Citation: BMC Developmental Biology 2017 17:8

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  4. Content type: Research article

    Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult...

    Authors: Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun and Maoping Chu

    Citation: BMC Developmental Biology 2016 16:41

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  5. Content type: Research article

    Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in in...

    Authors: Kartik Gupta, Vijaya Satish Sekhar Pilli and Gopala Krishna Aradhyam

    Citation: BMC Developmental Biology 2016 16:39

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  6. Content type: Research article

    Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseas...

    Authors: Andrew Robson, Nick D. L. Owens, Susan J. Baserga, Mustafa K. Khokha and John N. Griffin

    Citation: BMC Developmental Biology 2016 16:38

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  7. Content type: Research article

    Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output ...

    Authors: Karen Beets, Michael W. Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M. Chuva de Sousa Lopes, Lieve Umans and An Zwijsen

    Citation: BMC Developmental Biology 2016 16:34

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  8. Content type: Research article

    Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian ki...

    Authors: Irina I. Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko and Seppo J. Vainio

    Citation: BMC Developmental Biology 2016 16:30

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  9. Content type: Research article

    There is a gap in knowledge regarding the cardiovascular system in fish conjoined twins, and regarding the cardiovascular morphogenesis of conjoined twins in general. We examined the cardiovascular system in a...

    Authors: Per Gunnar Fjelldal, Monica F. Solberg, Tom Hansen, Tone Vågseth, Kevin Alan Glover and Harald Kryvi

    Citation: BMC Developmental Biology 2016 16:25

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  10. Content type: Research article

    Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development of benign skin fibrofolliculomas, multiple lung and kidney cysts, spontaneous pneumothorax and ...

    Authors: Emma J. Kenyon, Monique N. H. Luijten, Harmeet Gill, Nan Li, Matthew Rawlings, James C. Bull, Yavor Hadzhiev, Maurice A. M. van Steensel, Eamonn Maher and Ferenc Mueller

    Citation: BMC Developmental Biology 2016 16:23

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  11. Content type: Research article

    Current knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an ex...

    Authors: Inga Langner, Thomas Stahnke, Oliver Stachs, Tobias Lindner, Jens-Peter Kühn, Simon Kim, Andreas Wree and Soenke Langner

    Citation: BMC Developmental Biology 2016 16:21

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  12. Content type: Research article

    The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. ...

    Authors: Shannon W. Davis, Amanda H. Mortensen, Jessica L. Keisler, Amanda L. Zacharias, Philip J. Gage, Ken-ichi Yamamura and Sally A. Camper

    Citation: BMC Developmental Biology 2016 16:16

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  13. Content type: Research article

    Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early be...

    Authors: Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C. Slavkin and Kazuhisa Bessho

    Citation: BMC Developmental Biology 2016 16:14

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  14. Content type: Methodology article

    The correct evaluation of mineralization is fundamental for the study of skeletal development, maintenance, and regeneration. Current methods to visualize mineralized tissue in zebrafish rely on: 1) fixed spec...

    Authors: A. Bensimon-Brito, J. Cardeira, G. Dionísio, A. Huysseune, M. L. Cancela and P. E. Witten

    Citation: BMC Developmental Biology 2016 16:2

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  15. Content type: Research article

    It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase the complexity of the genetic network, thus lead to greater complexity of teeth. ...

    Authors: Ang Li, Ye Li, Tieli Song, Fu Wang, Dayong Liu, Zhipeng Fan, San Cheng, Chunmei Zhang, Jinsong Wang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2015 15:51

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  16. Content type: Methodology article

    The vertebrate heart consists of three cell layers: the innermost endothelium, the contractile myocardium and the outermost epicardium. The epicardium is vital for heart development and function, and forms fro...

    Authors: Monica S. Yue, Jessica S. Plavicki, Xin-yi Li, Richard E. Peterson and Warren Heideman

    Citation: BMC Developmental Biology 2015 15:50

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  17. Content type: Research article

    Development of the valves and septa of the heart depends on the formation and remodeling of the endocardial cushions in the atrioventricular canal and outflow tract. These cushions are populated by mesenchyme ...

    Authors: Ryan J. Coram, Samantha J. Stillwagon, Anuradha Guggilam, Michael W. Jenkins, Maurice S. Swanson and Andrea N. Ladd

    Citation: BMC Developmental Biology 2015 15:36

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  18. Content type: Research article

    In multiple vertebrate organisms, including chick, Xenopus, and zebrafish, Fibroblast Growth Factor (FGF) and Wnt signaling cooperate during formation of the otic placode. However, in the mouse, although FGF sign...

    Authors: Kevin D. Wright, Amanda A. Mahoney Rogers, Jian Zhang and Katherine Shim

    Citation: BMC Developmental Biology 2015 15:33

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  19. Content type: Commentary

    Recent studies have identified epithelial stem and progenitor cell populations of the lung. We are just beginning to understand the mechanisms that regulate their homeostatic, regenerative and maladaptive beha...

    Authors: Matt L. Donne, Andrew J. Lechner and Jason R. Rock

    Citation: BMC Developmental Biology 2015 15:32

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  20. Content type: Research article

    It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visu...

    Authors: Jelly HM Soffers, Jill PJM Hikspoors, Hayelom K. Mekonen, S. Eleonore Koehler and Wouter H. Lamers

    Citation: BMC Developmental Biology 2015 15:31

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  21. Content type: Research article

    Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65D...

    Authors: Renita C. Polk, Peter Gergics, Jeffrey D. Steimle, Huiqing Li, Ivan P. Moskowitz, Sally A. Camper and Roger H. Reeves

    Citation: BMC Developmental Biology 2015 15:30

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  22. Content type: Methodology article

    Mapping of tissue structure at the cellular, circuit, and organ-wide scale is important for understanding physiological and biological functions. A bio-electrochemical technique known as CLARITY used for three...

    Authors: Hyunsu Lee, Jae-Hyung Park, Incheol Seo, Sun-Hyun Park and Shin Kim

    Citation: BMC Developmental Biology 2014 14:48

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  23. Content type: Research article

    Identification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.

    Authors: Gautam K Malhotra, Xiangshan Zhao, Emily Edwards, Janel L Kopp, Mayumi Naramura, Maike Sander, Hamid Band and Vimla Band

    Citation: BMC Developmental Biology 2014 14:47

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  24. Content type: Research article

    In standard cell division, the cells undergo karyokinesis and then cytokinesis. Some cells, however, such as cardiomyocytes and hepatocytes, can produce binucleate cells by going through mitosis without cytoki...

    Authors: Kiichiro Taniguchi, Akihiko Kokuryo, Takao Imano, Ryunosuke Minami, Hideki Nakagoshi and Takashi Adachi-Yamada

    Citation: BMC Developmental Biology 2014 14:46

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  25. Content type: Research article

    The switch from cartilage template to bone during endochondral ossification of the growth plate requires a dynamic and close interaction between cartilage and the developing vasculature. Vascular invasion of t...

    Authors: Sonja M Walzer, Erdal Cetin, Ruth Grübl-Barabas, Irene Sulzbacher, Beate Rueger, Werner Girsch, Stefan Toegel, Reinhard Windhager and Michael B Fischer

    Citation: BMC Developmental Biology 2014 14:36

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  26. Content type: Methodology article

    Morphometric quantification of subtle craniofacial variation in studies of experimentally modified embryonic mice has proved valuable in determining the effects of developmental perturbations on craniofacial m...

    Authors: Christopher J Percival, Rebecca Green, Ralph Marcucio and Benedikt Hallgrímsson

    Citation: BMC Developmental Biology 2014 14:31

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  27. Content type: Research article

    The Drosophila heart (dorsal vessel) is a relatively simple tubular organ that serves as a model for several aspects of cardiogenesis. Cardiac morphogenesis, proper heart function and stability require structural...

    Authors: Dominik Hollfelder, Manfred Frasch and Ingolf Reim

    Citation: BMC Developmental Biology 2014 14:26

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  28. Content type: Research article

    The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from a...

    Authors: Xiao Qi Wang, Kwok Kin Chan, Xiaoyan Ming, Vincent CH Lui, Randy YC Poon, Chung Mau Lo, Chris Norbury and Ronnie TP Poon

    Citation: BMC Developmental Biology 2014 14:23

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  29. Content type: Research article

    The outermost layer of the vertebrate heart, the epicardium, forms from a cluster of progenitor cells termed the proepicardium (PE). PE cells migrate onto the myocardium to give rise to the epicardium. Impaire...

    Authors: Jessica S Plavicki, Peter Hofsteen, Monica S Yue, Kevin A Lanham, Richard E Peterson and Warren Heideman

    Citation: BMC Developmental Biology 2014 14:18

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  30. Content type: Research article

    The development of blood flow in the heart is crucial for heart function and embryonic survival. Recent studies have revealed the importance of the extracellular matrix and the mechanical stress applied to the...

    Authors: Tomomi Watanabe-Asaka, Yoshio Sekiya, Hironori Wada, Takako Yasuda, Ikuya Okubo, Shoji Oda and Hiroshi Mitani

    Citation: BMC Developmental Biology 2014 14:12

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  31. Content type: Research article

    Flatfish metamorphosis is a hormone regulated post-embryonic developmental event that transforms a symmetric larva into an asymmetric juvenile. In altricial-gastric teleost fish, differentiation of the stomach...

    Authors: Ana S Gomes, Yuko Kamisaka, Torstein Harboe, Deborah M Power and Ivar Rønnestad

    Citation: BMC Developmental Biology 2014 14:11

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  32. Content type: Research article

    Diacylglycerol kinase (DGK) is a key enzyme that regulates diacylglycerol (DG) turnover and is involved in a variety of physiological functions. The isoform DGKθ has a unique domain structure and is the sole m...

    Authors: Shuji Ueda, Becky Tu-Sekine, Minoru Yamanoue, Daniel M Raben and Yasuhito Shirai

    Citation: BMC Developmental Biology 2013 13:35

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  33. Content type: Research article

    Ecdysone triggers transcriptional changes via the ecdysone receptor (EcR) to coordinate developmental programs of apoptosis, cell cycle and differentiation. Data suggests EcR affects cell cycle gene expression...

    Authors: Naomi C Mitchell, Jane I Lin, Olga Zaytseva, Nicola Cranna, Amanda Lee and Leonie M Quinn

    Citation: BMC Developmental Biology 2013 13:28

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  34. Content type: Database

    The vertebrate craniofacial skeleton may exhibit anatomical complexity and diversity, but its genesis and evolution can be understood through careful dissection of developmental programs at cellular resolution...

    Authors: B Frank Eames, April DeLaurier, Bonnie Ullmann, Tyler R Huycke, James T Nichols, John Dowd, Marcie McFadden, Mark M Sasaki and Charles B Kimmel

    Citation: BMC Developmental Biology 2013 13:23

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  35. Content type: Research article

    Extracellular leucine-rich repeat (eLRR) proteins are a highly diverse superfamily of membrane-associated or secreted proteins. In the membrane-associated eLRR proteins, the leucine-rich repeat motifs interact...

    Authors: Chris R Gissendanner and Tram Do Kelley

    Citation: BMC Developmental Biology 2013 13:21

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  36. Content type: Research article

    MicroRNAs play important roles in regulating biological processes, including organ morphogenesis and maturation. However, little is known about specific pathways regulated by miRNA during lung development. Bet...

    Authors: Sana Mujahid, Tanya Logvinenko, MaryAnn V Volpe and Heber C Nielsen

    Citation: BMC Developmental Biology 2013 13:13

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  37. Content type: Research article

    Our current knowledge on tooth development derives primarily from studies in mice. Very little is known about gene expression and function during human odontogenesis. Sonic Hedgehog (SHH) signaling has been de...

    Authors: Xuefeng Hu, Shuo Zhang, Guimiao Chen, Chensheng Lin, Zhen Huang, YiPing Chen and Yanding Zhang

    Citation: BMC Developmental Biology 2013 13:11

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  38. Content type: Research article

    Thyroid hormones regulate growth and development. However, the molecular mechanisms by which thyroid hormone regulates cell structural development are not fully understood. The mammalian cochlea is an intrigui...

    Authors: Katherine B Szarama, Núria Gavara, Ronald S Petralia, Richard S Chadwick and Matthew W Kelley

    Citation: BMC Developmental Biology 2013 13:6

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  39. Content type: Research article

    Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers. Ac...

    Authors: Kelly J Gauger, Akihiko Shimono, Giovanna M Crisi and Sallie Smith Schneider

    Citation: BMC Developmental Biology 2012 12:25

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  40. Content type: Research article

    Valvulogenesis and septation in the developing heart depend on the formation and remodeling of endocardial cushions in the atrioventricular canal (AVC) and outflow tract (OFT). These cushions are invaded by a ...

    Authors: Kathryn E LeMasters, Yotam Blech-Hermoni, Samantha J Stillwagon, Natalie A Vajda and Andrea N Ladd

    Citation: BMC Developmental Biology 2012 12:22

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  41. Content type: Research article

    The lung and thyroid are derived from the anterior endoderm. Retinoic acid and Fgf signalling are known to be essential for development of the lung in mouse but little is known on how the lung and thyroid are ...

    Authors: Jean H Wang, Steven J Deimling, Nicole E D'Alessandro, Lin Zhao, Fred Possmayer and Thomas A Drysdale

    Citation: BMC Developmental Biology 2011 11:75

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  42. Content type: Research article

    We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming...

    Authors: Samantha Maragh, Ronald A Miller, Seneca L Bessling, David M McGaughey, Marja W Wessels, Bianca de Graaf, Eric A Stone, Aida M Bertoli-Avella, John D Gearhart, Shannon Fisher and Andrew S McCallion

    Citation: BMC Developmental Biology 2011 11:62

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  43. Content type: Research article

    Valuable insights into the complex process of retinal vascular development can be gained using models with abnormal retinal vasculature. Two such models are the recently described mouse lines with mutations in La...

    Authors: Malia M Edwards, D Scott McLeod, Rhonda Grebe, Céline Heng, Olivier Lefebvre and Gerard A Lutty

    Citation: BMC Developmental Biology 2011 11:60

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  44. Content type: Research article

    Sox6 is a multi-faceted transcription factor involved in the terminal differentiation of many different cell types in vertebrates. It has been suggested that in mice as well as in zebrafish Sox6 plays a role i...

    Authors: Chung-Il An, Yao Dong and Nobuko Hagiwara

    Citation: BMC Developmental Biology 2011 11:59

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  45. Content type: Research article

    During liver development, intrahepatic bile ducts are thought to arise by a unique asymmetric mode of cholangiocyte tubulogenesis characterized by a series of remodeling stages. Moreover, in liver diseases, ce...

    Authors: Peter S Vestentoft, Peter Jelnes, Branden M Hopkinson, Ben Vainer, Kjeld Møllgård, Bjørn Quistorff and Hanne C Bisgaard

    Citation: BMC Developmental Biology 2011 11:56

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  46. Content type: Research article

    Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice deficient for Arx do not develop any alpha-cells whereas beta- and delta...

    Authors: Simon Kordowich, Patrick Collombat, Ahmed Mansouri and Palle Serup

    Citation: BMC Developmental Biology 2011 11:52

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  47. Content type: Research article

    In a recent genomic study, Leung et al. used a factorial microarray analysis to identify Smarca4 (Brg1)-regulated genes in micro-dissected zebrafish retinas. Two hundred and fifty nine genes were grouped in th...

    Authors: Monica R Hensley, Farida Emran, Sylvia Bonilla, Liyun Zhang, Wenxuan Zhong, Paul Grosu, John E Dowling and Yuk Fai Leung

    Citation: BMC Developmental Biology 2011 11:45

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