This section considers studies in the development of organs and tissues.

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  1. Research article

    Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing

    The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However,...

    Linda Sharp, Thomas Pratt, Gillian E. MacKay, Margaret A. Keighren, Jean H. Flockhart, Emma J. Chandler, David J. Price, John O. Mason and John D. West

    BMC Developmental Biology 2017 17:8

    Published on: 29 June 2017

  2. Research article

    Microarray analysis reveals a potential role of LncRNAs expression in cardiac cell proliferation

    Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult...

    Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun and Maoping Chu

    BMC Developmental Biology 2016 16:41

    Published on: 18 November 2016

  3. Research article

    Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis

    Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseas...

    Andrew Robson, Nick D. L. Owens, Susan J. Baserga, Mustafa K. Khokha and John N. Griffin

    BMC Developmental Biology 2016 16:38

    Published on: 26 October 2016

  4. Research article

    BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

    Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output ...

    Karen Beets, Michael W. Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M. Chuva de Sousa Lopes, Lieve Umans and An Zwijsen

    BMC Developmental Biology 2016 16:34

    Published on: 10 October 2016

  5. Research article

    Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis

    Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian ki...

    Irina I. Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko and Seppo J. Vainio

    BMC Developmental Biology 2016 16:30

    Published on: 31 August 2016

  6. Research article

    Salmonid fish: model organisms to study cardiovascular morphogenesis in conjoined twins?

    There is a gap in knowledge regarding the cardiovascular system in fish conjoined twins, and regarding the cardiovascular morphogenesis of conjoined twins in general. We examined the cardiovascular system in a...

    Per Gunnar Fjelldal, Monica F. Solberg, Tom Hansen, Tone Vågseth, Kevin Alan Glover and Harald Kryvi

    BMC Developmental Biology 2016 16:25

    Published on: 16 July 2016

  7. Research article

    Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis

    Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development of benign skin fibrofolliculomas, multiple lung and kidney cysts, spontaneous pneumothorax and ...

    Emma J. Kenyon, Monique N. H. Luijten, Harmeet Gill, Nan Li, Matthew Rawlings, James C. Bull, Yavor Hadzhiev, Maurice A. M. van Steensel, Eamonn Maher and Ferenc Mueller

    BMC Developmental Biology 2016 16:23

    Published on: 8 July 2016

  8. Research article

    MR microscopy of the human fetal upper extremity – a proof-of-principle study

    Current knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an ex...

    Inga Langner, Thomas Stahnke, Oliver Stachs, Tobias Lindner, Jens-Peter Kühn, Simon Kim, Andreas Wree and Soenke Langner

    BMC Developmental Biology 2016 16:21

    Published on: 18 June 2016

  9. Research article

    β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis

    The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. ...

    Shannon W. Davis, Amanda H. Mortensen, Jessica L. Keisler, Amanda L. Zacharias, Philip J. Gage, Ken-ichi Yamamura and Sally A. Camper

    BMC Developmental Biology 2016 16:16

    Published on: 16 May 2016

  10. Research article

    Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis

    Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early be...

    Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C. Slavkin and Kazuhisa Bessho

    BMC Developmental Biology 2016 16:14

    Published on: 13 May 2016

  11. Methodology article

    Revisiting in vivo staining with alizarin red S - a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration

    The correct evaluation of mineralization is fundamental for the study of skeletal development, maintenance, and regeneration. Current methods to visualize mineralized tissue in zebrafish rely on: 1) fixed spec...

    A. Bensimon-Brito, J. Cardeira, G. Dionísio, A. Huysseune, M. L. Cancela and P. E. Witten

    BMC Developmental Biology 2016 16:2

    Published on: 19 January 2016

  12. Research article

    Identification of differential microRNA expression during tooth morphogenesis in the heterodont dentition of miniature pigs, SusScrofa

    It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase the complexity of the genetic network, thus lead to greater complexity of teeth. ...

    Ang Li, Ye Li, Tieli Song, Fu Wang, Dayong Liu, Zhipeng Fan, San Cheng, Chunmei Zhang, Jinsong Wang, Junqi He and Songlin Wang

    BMC Developmental Biology 2015 15:51

    Published on: 29 December 2015

  13. Methodology article

    A co-culture assay of embryonic zebrafish hearts to assess migration of epicardial cells in vitro

    The vertebrate heart consists of three cell layers: the innermost endothelium, the contractile myocardium and the outermost epicardium. The epicardium is vital for heart development and function, and forms fro...

    Monica S. Yue, Jessica S. Plavicki, Xin-yi Li, Richard E. Peterson and Warren Heideman

    BMC Developmental Biology 2015 15:50

    Published on: 29 December 2015

  14. Research article

    Muscleblind-like 1 is required for normal heart valve development in vivo

    Development of the valves and septa of the heart depends on the formation and remodeling of the endocardial cushions in the atrioventricular canal and outflow tract. These cushions are populated by mesenchyme ...

    Ryan J. Coram, Samantha J. Stillwagon, Anuradha Guggilam, Michael W. Jenkins, Maurice S. Swanson and Andrea N. Ladd

    BMC Developmental Biology 2015 15:36

    Published on: 15 October 2015

  15. Commentary

    Evidence for lung epithelial stem cell niches

    Recent studies have identified epithelial stem and progenitor cell populations of the lung. We are just beginning to understand the mechanisms that regulate their homeostatic, regenerative and maladaptive beha...

    Matt L. Donne, Andrew J. Lechner and Jason R. Rock

    BMC Developmental Biology 2015 15:32

    Published on: 16 September 2015

  16. Research article

    The growth pattern of the human intestine and its mesentery

    It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visu...

    Jelly HM Soffers, Jill PJM Hikspoors, Hayelom K. Mekonen, S. Eleonore Koehler and Wouter H. Lamers

    BMC Developmental Biology 2015 15:31

    Published on: 22 August 2015

  17. Research article

    The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

    Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65D...

    Renita C. Polk, Peter Gergics, Jeffrey D. Steimle, Huiqing Li, Ivan P. Moskowitz, Sally A. Camper and Roger H. Reeves

    BMC Developmental Biology 2015 15:30

    Published on: 25 July 2015

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