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Neural development

Section edited by Jean-François Brunet

This section considers studies in the development of the nervous system.

  1. Content type: Research article

    Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the ...

    Authors: Melanie Morris, Ariel Shaw, Madison Lambert, Haley Halperin Perry, Eve Lowenstein, David Valenzuela and Norma Andrea Velazquez-Ulloa

    Citation: BMC Developmental Biology 2018 18:13

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  2. Content type: Research article

    MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the ...

    Authors: A. Alwin Prem Anand, Carola Huber, John Asnet Mary, Nancy Gallus, Christoph Leucht, Ruth Klafke, Bernhard Hirt and Andrea Wizenmann

    Citation: BMC Developmental Biology 2018 18:3

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  3. Content type: Research article

    Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC...

    Authors: Barbara F. Fonseca, Gérard Couly and Elisabeth Dupin

    Citation: BMC Developmental Biology 2017 17:13

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  4. Content type: Research article

    Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of o...

    Authors: Rachael Lumb, Sam Buckberry, Genevieve Secker, David Lawrence and Quenten Schwarz

    Citation: BMC Developmental Biology 2017 17:5

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  5. Content type: Research article

    During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expres...

    Authors: Jimena Monzón-Sandoval, Atahualpa Castillo-Morales, Araxi O. Urrutia and Humberto Gutierrez

    Citation: BMC Developmental Biology 2016 16:13

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  6. Content type: Research article

    Magnetic resonance imaging (MRI) has many advantages in the research of in vivo embryonic brain development, specifically its noninvasive aspects and ability to avoid skeletal interference. However, few studie...

    Authors: Zien Zhou, Zengai Chen, Jiehui Shan, Weiwei Ma, Lei Li, Jinyan Zu and Jianrong Xu

    Citation: BMC Developmental Biology 2015 15:29

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  7. Content type: Research article

    Members of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information abo...

    Authors: Anil Sharma, Chrisna J LeVaillant, Giles W Plant and Alan R Harvey

    Citation: BMC Developmental Biology 2014 14:34

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:39

  8. Content type: Research article

    Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or functi...

    Authors: Sarika Tiwari, Subramanian Dharmarajan, Mahesh Shivanna, Deborah C Otteson and Teri L Belecky-Adams

    Citation: BMC Developmental Biology 2014 14:30

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  9. Content type: Research article

    The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation o...

    Authors: Steven E Weicksel, Ankit Gupta, Denise A Zannino, Scot A Wolfe and Charles G Sagerström

    Citation: BMC Developmental Biology 2014 14:25

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  10. Content type: Research article

    Essentially nothing is known about the genetic regulation of olfactory system development in vector mosquitoes, which use olfactory cues to detect blood meal hosts. Studies in Drosophila melanogaster have identif...

    Authors: Keshava Mysore, Emily Andrews, Ping Li and Molly Duman-Scheel

    Citation: BMC Developmental Biology 2014 14:9

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  11. Content type: Research article

    LIM domain binding protein 1 (LDB1) is a transcriptional co-factor, which interacts with multiple transcription factors and other proteins containing LIM domains. Complete inactivation of Ldb1 in mice resulted in...

    Authors: Asma Almaidhan, Jeffry Cesario, Andre Landin Malt, Yangu Zhao, Neeti Sharma, Veronica Choi and Juhee Jeong

    Citation: BMC Developmental Biology 2014 14:3

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  12. Content type: Research article

    Members of the vertebrate Numb family of cell fate determinants serve multiple functions throughout early embryogenesis, including an essential role in the development of the nervous system. The Numb proteins ...

    Authors: Frank Nieber, Marie Hedderich, Olaf Jahn, Tomas Pieler and Kristine A Henningfeld

    Citation: BMC Developmental Biology 2013 13:36

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  13. Content type: Research article

    The reiterated architecture of cranial motor neurons aligns with the segmented structure of the embryonic vertebrate hindbrain. Anterior-posterior identity of cranial motor neurons depends, in part, on retinoi...

    Authors: Danna L Drummond, Caroline S Cheng, Lyndsay G Selland, Jennifer C Hocking, Lisa B Prichard and Andrew J Waskiewicz

    Citation: BMC Developmental Biology 2013 13:31

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  14. Content type: Methodology article

    The explanted, developing rodent retina provides an efficient and accessible preparation for use in gene transfer and pharmacological experimentation. Many of the features of normal development are retained in...

    Authors: Philip EB Nickerson, Kara M Ronellenfitch, Nicklaus F Csuzdi, Jamie D Boyd, Perry L Howard, Kerry R Delaney and Robert L Chow

    Citation: BMC Developmental Biology 2013 13:24

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  15. Content type: Research article

    Group B Sox domain transcription factors play important roles in metazoan central nervous system development. They are, however, difficult to study as mutations often have pleiotropic effects and other Sox fam...

    Authors: Shih Pei Shen, Jelena Aleksic and Steven Russell

    Citation: BMC Developmental Biology 2013 13:1

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  16. Content type: Research article

    The molecular mechanism that initiates the formation of the vertebrate central nervous system has long been debated. Studies in Xenopus and mouse demonstrate that inhibition of BMP signaling is sufficient to indu...

    Authors: Crystal D Rogers, George S Ferzli and Elena S Casey

    Citation: BMC Developmental Biology 2011 11:74

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  17. Content type: Research article

    Retinoic acid (RA) is important for vertebrate eye morphogenesis and is a regulator of photoreceptor development in the retina. In the zebrafish, RA treatment of postmitotic photoreceptor precursors has been s...

    Authors: Craig B Stevens, David A Cameron and Deborah L Stenkamp

    Citation: BMC Developmental Biology 2011 11:51

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  18. Content type: Research article

    We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has ...

    Authors: Hyun-Taek Kim, Ju-Hoon So, Seung-Hyun Jung, Dae-Gwon Ahn, Wansoo Koh, Nam-Soon Kim, Soo-Hyun Kim, Soojin Lee and Cheol-Hee Kim

    Citation: BMC Developmental Biology 2011 11:49

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  19. Content type: Methodology article

    Whole-mount in situ hybridization (WISH) is extensively used to characterize gene expression patterns in developing and adult brain and other tissues. To obtain an idea whether a novel gene might be involved in s...

    Authors: Gilbert Lauter, Iris Söll and Giselbert Hauptmann

    Citation: BMC Developmental Biology 2011 11:43

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  20. Content type: Research article

    Neurogenesis control and the prevention of premature differentiation in the vertebrate embryo are crucial processes, allowing the formation of late-born cell types and ensuring the correct shape and cytoarchit...

    Authors: Katharine J Webb, Marion Coolen, Christian J Gloeckner, Christian Stigloher, Brigitte Bahn, Stefanie Topp, Marius Ueffing and Laure Bally-Cuif

    Citation: BMC Developmental Biology 2011 11:27

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  21. Content type: Research article

    The embryonic organizer (i.e., Spemann organizer) has a pivotal role in the establishment of the dorsoventral (DV) axis through the coordination of BMP signaling. However, as impaired organizer function also r...

    Authors: Máté Varga, Shingo Maegawa and Eric S Weinberg

    Citation: BMC Developmental Biology 2011 11:26

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