Neural development

Section edited by Jean-François Brunet

This section considers studies in the development of the nervous system.

  1. Research article

    Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels

    Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of o...

    Rachael Lumb, Sam Buckberry, Genevieve Secker, David Lawrence and Quenten Schwarz

    BMC Developmental Biology 2017 17:5

    Published on: 13 April 2017

  2. Research article

    Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

    During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expres...

    Jimena Monzón-Sandoval, Atahualpa Castillo-Morales, Araxi O. Urrutia and Humberto Gutierrez

    BMC Developmental Biology 2016 16:13

    Published on: 12 May 2016

  3. Research article

    Monitoring brain development of chick embryos in vivo using 3.0 T MRI: subdivision volume change and preliminary structural quantification using DTI

    Magnetic resonance imaging (MRI) has many advantages in the research of in vivo embryonic brain development, specifically its noninvasive aspects and ability to avoid skeletal interference. However, few studie...

    Zien Zhou, Zengai Chen, Jiehui Shan, Weiwei Ma, Lei Li, Jinyan Zu and Jianrong Xu

    BMC Developmental Biology 2015 15:29

    Published on: 25 July 2015

  4. Research article

    Changes in expression of Class 3 Semaphorins and their receptors during development of the rat retina and superior colliculus

    Members of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information abo...

    Anil Sharma, Chrisna J LeVaillant, Giles W Plant and Alan R Harvey

    BMC Developmental Biology 2014 14:34

    Published on: 26 July 2014

    The Erratum to this article has been published in BMC Developmental Biology 2014 14:39

  5. Research article

    Histone deacetylase expression patterns in developing murine optic nerve

    Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or functi...

    Sarika Tiwari, Subramanian Dharmarajan, Mahesh Shivanna, Deborah C Otteson and Teri L Belecky-Adams

    BMC Developmental Biology 2014 14:30

    Published on: 9 July 2014

  6. Research article

    Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish

    The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation o...

    Steven E Weicksel, Ankit Gupta, Denise A Zannino, Scot A Wolfe and Charles G Sagerström

    BMC Developmental Biology 2014 14:25

    Published on: 5 June 2014

  7. Research article

    Chitosan/siRNA nanoparticle targeting demonstrates a requirement for single-minded during larval and pupal olfactory system development of the vector mosquito Aedes aegypti

    Essentially nothing is known about the genetic regulation of olfactory system development in vector mosquitoes, which use olfactory cues to detect blood meal hosts. Studies in Drosophila melanogaster have identif...

    Keshava Mysore, Emily Andrews, Ping Li and Molly Duman-Scheel

    BMC Developmental Biology 2014 14:9

    Published on: 19 February 2014

  8. Research article

    Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation

    LIM domain binding protein 1 (LDB1) is a transcriptional co-factor, which interacts with multiple transcription factors and other proteins containing LIM domains. Complete inactivation of Ldb1 in mice resulted in...

    Asma Almaidhan, Jeffry Cesario, Andre Landin Malt, Yangu Zhao, Neeti Sharma, Veronica Choi and Juhee Jeong

    BMC Developmental Biology 2014 14:3

    Published on: 17 January 2014

  9. Research article

    NumbL is essential for Xenopusprimary neurogenesis

    Members of the vertebrate Numb family of cell fate determinants serve multiple functions throughout early embryogenesis, including an essential role in the development of the nervous system. The Numb proteins ...

    Frank Nieber, Marie Hedderich, Olaf Jahn, Tomas Pieler and Kristine A Henningfeld

    BMC Developmental Biology 2013 13:36

    Published on: 14 October 2013

  10. Research article

    The role of Zic transcription factors in regulating hindbrain retinoic acid signaling

    The reiterated architecture of cranial motor neurons aligns with the segmented structure of the embryonic vertebrate hindbrain. Anterior-posterior identity of cranial motor neurons depends, in part, on retinoi...

    Danna L Drummond, Caroline S Cheng, Lyndsay G Selland, Jennifer C Hocking, Lisa B Prichard and Andrew J Waskiewicz

    BMC Developmental Biology 2013 13:31

    Published on: 12 August 2013

  11. Methodology article

    Live imaging and analysis of postnatal mouse retinal development

    The explanted, developing rodent retina provides an efficient and accessible preparation for use in gene transfer and pharmacological experimentation. Many of the features of normal development are retained in...

    Philip EB Nickerson, Kara M Ronellenfitch, Nicklaus F Csuzdi, Jamie D Boyd, Perry L Howard, Kerry R Delaney and Robert L Chow

    BMC Developmental Biology 2013 13:24

    Published on: 10 June 2013

  12. Research article

    The response of early neural genes to FGF signaling or inhibition of BMP indicate the absence of a conserved neural induction module

    The molecular mechanism that initiates the formation of the vertebrate central nervous system has long been debated. Studies in Xenopus and mouse demonstrate that inhibition of BMP signaling is sufficient to indu...

    Crystal D Rogers, George S Ferzli and Elena S Casey

    BMC Developmental Biology 2011 11:74

    Published on: 15 December 2011

  13. Research article

    Cug2 is essential for normal mitotic control and CNS development in zebrafish

    We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has ...

    Hyun-Taek Kim, Ju-Hoon So, Seung-Hyun Jung, Dae-Gwon Ahn, Wansoo Koh, Nam-Soon Kim, Soo-Hyun Kim, Soojin Lee and Cheol-Hee Kim

    BMC Developmental Biology 2011 11:49

    Published on: 15 August 2011

  14. Research article

    The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish

    Neurogenesis control and the prevention of premature differentiation in the vertebrate embryo are crucial processes, allowing the formation of late-born cell types and ensuring the correct shape and cytoarchit...

    Katharine J Webb, Marion Coolen, Christian J Gloeckner, Christian Stigloher, Brigitte Bahn, Stefanie Topp, Marius Ueffing and Laure Bally-Cuif

    BMC Developmental Biology 2011 11:27

    Published on: 17 May 2011