Skip to main content


Gametogenesis and fertilization

This section considers studies in the development of gametes and the processes involved in fertilization continuing to implantation.

  1. Content type: Research article

    The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. elegans early embryos, PCN-1 accumul...

    Authors: Zuzana Kocsisova, Kerry Kornfeld and Tim Schedl

    Citation: BMC Developmental Biology 2018 18:12

    Published on:

  2. Content type: Research article

    Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20–30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses f...

    Authors: Marco Graziano, Raul Benito, Josep V. Planas and Arjan P. Palstra

    Citation: BMC Developmental Biology 2018 18:10

    Published on:

  3. Content type: Research article

    Cathepsin B is a lysosomal cysteine protease involved in apoptosis and oocytes which have lower developmental competence show higher expression of Cathepsin B. Furthermore, expression of Cathepsin B show a dec...

    Authors: M. Pezhman, S. M. Hosseini, S. Ostadhosseini, Sh. Rouhollahi Varnosfaderani, F. Sefid and M. H. Nasr-Esfahani

    Citation: BMC Developmental Biology 2017 17:10

    Published on:

  4. Content type: Research article

    Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that possess them. However, they have been lost in the ev...

    Authors: Sina Saari, Ana Andjelković, Geovana S. Garcia, Howard T. Jacobs and Marcos T. Oliveira

    Citation: BMC Developmental Biology 2017 17:9

    Published on:

  5. Content type: Research article

    An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migr...

    Authors: Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu and Da-Peng Li

    Citation: BMC Developmental Biology 2016 16:42

    Published on:

  6. Content type: Research article

    Sex determination in mammals requires expression of the Y-linked gene Sry in the bipotential genital ridges of the XY embryo. Even minor delay of the onset of Sry expression can result in XY sex reversal, highlig...

    Authors: Christian Larney, Timothy L. Bailey and Peter Koopman

    Citation: BMC Developmental Biology 2015 15:34

    Published on:

  7. Content type: Research article

    The sub-cortical maternal complex (SCMC), located in the subcortex of mouse oocytes and preimplantation embryos, is composed of at least four proteins encoded by maternal effect genes: OOEP, NLRP5/MATER, TLE6 ...

    Authors: Daniela Bebbere, Federica Ariu, Luisa Bogliolo, Laura Masala, Ombretta Murrone, Mauro Fattorini, Laura Falchi and Sergio Ledda

    Citation: BMC Developmental Biology 2014 14:40

    Published on:

  8. Content type: Research article

    The injection of Neb-colloostatin into T. molitor females causes gonadoinhibitory effects on ovarian development. This peptide inhibits intercellular space formation (patency) in follicular epithelium and results...

    Authors: Elżbieta Czarniewska, Grzegorz Rosiński, Elżbieta Gabała and Mariola Kuczer

    Citation: BMC Developmental Biology 2014 14:4

    Published on:

  9. Content type: Research article

    It has been proven that c-kit is crucial for proliferation, migration, survival and maturation of spermatogenic cells. A periodic expression of c-kit is observed from primordial germ cells (PGCs) to spermatogenet...

    Authors: Lei Zhang, Jiangjing Tang, Christopher J Haines, Huai Feng, Liangxue Lai, Xiaoming Teng and Yibing Han

    Citation: BMC Developmental Biology 2013 13:38

    Published on:

  10. Content type: Research article

    The 14-3-3 (YWHA) proteins are central mediators in various cellular signaling pathways regulating development and growth, including cell cycle regulation. We previously reported that all seven mammalian 14-3-...

    Authors: Santanu De and Douglas Kline

    Citation: BMC Developmental Biology 2013 13:10

    Published on:

    The Erratum to this article has been published in BMC Developmental Biology 2014 14:20

  11. Content type: Research article

    In the male germ line of Drosophila chromatin remains decondensed and highly transcribed during meiotic prophase until it is rapidly compacted. A large proportion of the cell cycle-regulated histone H3.1 is repla...

    Authors: Wolfgang Hennig and Alexandra Weyrich

    Citation: BMC Developmental Biology 2013 13:7

    Published on:

  12. Content type: Research article

    In mammals, R-spondin (Rspo), an activator of the Wnt/β-catenin signaling pathway, has been shown to be involved in ovarian differentiation. However, the role of the Rspo/Wnt/β-catenin signaling pathway in fis...

    Authors: Linyan Zhou, Tapas Charkraborty, Xiangguo Yu, Limin Wu, Gang Liu, Sipra Mohapatra, Deshou Wang and Yoshitaka Nagahama

    Citation: BMC Developmental Biology 2012 12:36

    Published on:

  13. Content type: Research article

    The proper balance of autophagy, a lysosome-mediated degradation process, is indispensable for oogenesis in Drosophila. We recently demonstrated that egg development depends on autophagy in the somatic follicle c...

    Authors: Julia MI Barth, Ernst Hafen and Katja Köhler

    Citation: BMC Developmental Biology 2012 12:35

    Published on:

  14. Content type: Research article

    Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and human...

    Authors: William A O'Hara, Walid J Azar, Richard R Behringer, Marilyn B Renfree and Andrew J Pask

    Citation: BMC Developmental Biology 2011 11:72

    Published on:

  15. Content type: Research article

    Progesterone triggers resumption of the first meiotic division in the Rana pipiens oocyte by binding to the N-terminal external loop of the catalytic subunit of Na/K-ATPase, releasing a cascade of lipid second me...

    Authors: Gene A Morrill, Terry L Dowd, Adele B Kostellow and Raj K Gupta

    Citation: BMC Developmental Biology 2011 11:67

    Published on:

  16. Content type: Research article

    Two stages of genome activation have been identified in the mouse embryo. Specifically, minor transcriptional activation is evident at the one-cell stage and a second major episode of activation occurs at the ...

    Authors: Reza K Oqani, Hong R Kim, Yun F Diao, Chang S Park and Dong I Jin

    Citation: BMC Developmental Biology 2011 11:33

    Published on:

  17. Content type: Research article

    The gene transformer-2, which is involved in sex determination, has been studied in Drosophila, Musca, Ceratitis, Anastrepha and Lucilia. All these members of Diptera belong to the suborder Brachycera. In this wo...

    Authors: Iker Martín, María F Ruiz and Lucas Sánchez

    Citation: BMC Developmental Biology 2011 11:19

    Published on:

  18. Content type: Research article

    The C. elegans sperm protein SPE-42, a membrane protein of unknown structure and molecular function, is required for fertilization. Sperm from worms with spe-42 mutations appear normal but are unable to fertilize...

    Authors: Luke D Wilson, Jacqueline M Sackett, Bryce D Mieczkowski, Abigail L Richie, Kara Thoemke, Jon N Rumbley and Tim L Kroft

    Citation: BMC Developmental Biology 2011 11:10

    Published on: