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Early development

Section edited by Anna-Katerina Hadjantonakis

This section considers studies in all aspects of the early development of organisms, including embryonic and somite development.

Page 1 of 2

  1. Content type: Research article

    Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-...

    Authors: Paula Tríbulo, Gulnur Jumatayeva, Khoboso Lehloenya, James I. Moss, Veronica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2018 18:16

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  2. Content type: Research article

    Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite...

    Authors: Rita Alexandra Pinto, José Almeida-Santos, Raquel Lourenço and Leonor Saúde

    Citation: BMC Developmental Biology 2018 18:14

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  3. Content type: Research article

    Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome a...

    Authors: Xiaofen Hu, Li Ke, Zilong Wang and Zhijiang Zeng

    Citation: BMC Developmental Biology 2018 18:11

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  4. Content type: Research article

    Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growt...

    Authors: Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu and Jen-Her Lu

    Citation: BMC Developmental Biology 2018 18:5

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  5. Content type: Research article

    Over one third of all animal phyla utilize a mode of early embryogenesis called ‘spiral cleavage’ to divide the fertilized egg into embryonic cells with different cell fates. This mode is characterized by a se...

    Authors: Aron B. Nakama, Hsien-Chao Chou and Stephan Q. Schneider

    Citation: BMC Developmental Biology 2017 17:16

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  6. Content type: Research article

    The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fi...

    Authors: Joana Firmino, Carlos Carballo, Paula Armesto, Marco A. Campinho, Deborah M. Power and Manuel Manchado

    Citation: BMC Developmental Biology 2017 17:11

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  7. Content type: Research article

    Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. gly...

    Authors: Sita Thapa, Jayna A. Patel, Ursula Reuter-Carlson and Nathan E. Schroeder

    Citation: BMC Developmental Biology 2017 17:2

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  8. Content type: Research article

    Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Authors: Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    Citation: BMC Developmental Biology 2016 16:37

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  9. Content type: Research article

    Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    Authors: L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    Citation: BMC Developmental Biology 2016 16:36

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  10. Content type: Research article

    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Authors: Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    Citation: BMC Developmental Biology 2016 16:31

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  11. Content type: Research article

    Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Authors: Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    Citation: BMC Developmental Biology 2016 16:19

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  12. Content type: Research article

    Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Authors: Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    Citation: BMC Developmental Biology 2016 16:10

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  13. Content type: Research article

    Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting ...

    Authors: Carolin Schille, Jens Heller and Alexandra Schambony

    Citation: BMC Developmental Biology 2016 16:1

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  14. Content type: Methodology article

    Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, ro...

    Authors: Jens Popken, Maik Dahlhoff, Tuna Guengoer, Eckhard Wolf and Valeri Zakhartchenko

    Citation: BMC Developmental Biology 2015 15:46

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  15. Content type: Methodology article

    The GATA-binding factor 6 (Gata6) gene encodes a zinc finger transcription factor that often functions as a key regulator of lineage specification during development. It is the earliest known marker of the primit...

    Authors: Laina Freyer, Christian Schröter, Néstor Saiz, Nadine Schrode, Sonja Nowotschin, Alfonso Martinez-Arias and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2015 15:38

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  16. Content type: Research article

    Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in pri...

    Authors: Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane and Hitoshi Niwa

    Citation: BMC Developmental Biology 2015 15:37

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  17. Content type: Research article

    Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro res...

    Authors: Constantinos Economou, Anestis Tsakiridis, Filip J. Wymeersch, Sabrina Gordon-Keylock, Robert E Dewhurst, Dawn Fisher, Alexander Medvinsky, Andrew JH Smith and Valerie Wilson

    Citation: BMC Developmental Biology 2015 15:35

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  18. Content type: Research article

    The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate in various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrat...

    Authors: Cheng Cui, Xiuli Ren, Dajun Liu, Xin Deng, Xin Qin, Xiangyu Zhao, Enhua Wang and Bingzhi Yu

    Citation: BMC Developmental Biology 2014 14:33

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  19. Content type: Research article

    The retinal pigmented epithelium (RPE) is a rounded shaped structure in almost all lizards. In the New World dwarf geckos, this structure shows an unusual morphology. In addition to this ocular character, we d...

    Authors: Ricardo A Guerra-Fuentes, Juan D Daza and Aaron M Bauer

    Citation: BMC Developmental Biology 2014 14:29

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  20. Content type: Research article

    Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, infl...

    Authors: VC Padmakumar, Katelyn E Masiuk, Dror Luger, Christina Lee, Vincenzo Coppola, Lino Tessarollo, Shelley B Hoover, Irina Karavanova, Andres Buonanno, R Mark Simpson and Stuart H Yuspa

    Citation: BMC Developmental Biology 2014 14:24

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  21. Content type: Research article

    The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the proc...

    Authors: Tieli Song, Tingting Wu, Fulan Wei, Ang Li, Fu Wang, Yilin Xie, Dayong Liu, Zhipeng Fan, Xuejiu Wang, Shan Cheng, Chunmei Zhang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2014 14:16

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  22. Content type: Research article

    Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growt...

    Authors: Susan M Motch Perrine, Theodore M Cole III, Neus Martínez-Abadías, Kristina Aldridge, Ethylin Wang Jabs and Joan T Richtsmeier

    Citation: BMC Developmental Biology 2014 14:8

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  23. Content type: Research article

    Important knowledge about the role of vitamin A in vertebrate heart development has been obtained using the vitamin A-deficient avian in ovo model which enables the in vivo examination of very early stages of ver...

    Authors: Inese Cakstina, Una Riekstina, Martins Boroduskis, Ilva Nakurte, Janis Ancans, Maija H Zile and Indrikis Muiznieks

    Citation: BMC Developmental Biology 2014 14:10

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  24. Content type: Research article

    Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during embryonic development. In adult mice, KLF2 regulates expression of the tight junction protein occludin, which may allow KLF2 to ...

    Authors: Aditi R Chiplunkar, Benjamin C Curtis, Gabriel L Eades, Megan S Kane, Sean J Fox, Jack L Haar and Joyce A Lloyd

    Citation: BMC Developmental Biology 2013 13:40

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  25. Content type: Research article

    Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. Since its expression is lost in several cancer types, Dab2 has been suggested to be a tumor su...

    Authors: Robert Moore, Kathy Qi Cai, Wensi Tao, Elizabeth R Smith and Xiang-Xi Xu

    Citation: BMC Developmental Biology 2013 13:39

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  26. Content type: Research article

    The myotome is the primitive skeletal muscle that forms within the embryonic metameric body wall. It can be subdivided into an epaxial and hypaxial domain. It has been shown that the formation of the epaxial m...

    Authors: Qin Pu, Aisha Abduelmula, Maryna Masyuk, Carsten Theiss, Dieter Schwandulla, Michael Hans, Ketan Patel, Beate Brand-Saberi and Ruijin Huang

    Citation: BMC Developmental Biology 2013 13:37

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    The Erratum to this article has been published in BMC Developmental Biology 2013 13:41

  27. Content type: Methodology article

    Velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS) is caused by a 1.5-3 Mb microdeletion of chromosome 22q11.2, frequently referred to as 22q11.2 deletion syndrome (22q11DS). This region includes TBX1, a T-...

    Authors: Laina Freyer, Sonja Nowotschin, Melinda K Pirity, Antonio Baldini and Bernice E Morrow

    Citation: BMC Developmental Biology 2013 13:33

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  28. Content type: Research article

    Preimplantation bovine development is emerging as an attractive experimental model, yet little is known about the mechanisms underlying trophoblast (TE)/inner cell mass (ICM) segregation in cattle. To gain an ...

    Authors: Zofia E Madeja, Jaroslaw Sosnowski, Kamila Hryniewicz, Ewelina Warzych, Piotr Pawlak, Natalia Rozwadowska, Berenika Plusa and Dorota Lechniak

    Citation: BMC Developmental Biology 2013 13:32

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  29. Content type: Research article

    Aedes aegypti is the most important global vector of dengue virus infection in humans. Availability of the draft genome sequence of this mosquito provides unique opportunities to study different aspects of its bi...

    Authors: Brent W Harker, Susanta K Behura, Becky S deBruyn, Diane D Lovin, Akio Mori, Jeanne Romero-Severson and David W Severson

    Citation: BMC Developmental Biology 2013 13:29

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  30. Content type: Research article

    Protein kinase C epsilon (PKCϵ) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKCϵ is important in different con...

    Authors: Sergio Carracedo, Ursula Braun and Michael Leitges

    Citation: BMC Developmental Biology 2013 13:16

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  31. Content type: Methodology article

    Live imaging provides an essential methodology for understanding complex and dynamic cell behaviors and their underlying molecular mechanisms. Genetically-encoded reporter expressing mouse strains are an impor...

    Authors: Sonja Nowotschin, Panagiotis Xenopoulos, Nadine Schrode and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2013 13:15

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  32. Content type: Research article

    Tenm4 is a mouse homolog of the Drosophila gene Tenascin-m (Ten-m (Odd oz)), which functions in motor neuron routing. Recently, a genome-wide association analysis for bipolar disorder identified a new susceptibil...

    Authors: Hisashi Nakamura, Rita N Cook and Monica J Justice

    Citation: BMC Developmental Biology 2013 13:9

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  33. Content type: Research article

    Individual skeletal elements of the vertebrate limbs arise through a segmentation process introducing joints in specific locations. However, the molecular pathways controlling joint formation and subsequent jo...

    Authors: Akinori Kan, Toshiyuki Ikeda, Atsushi Fukai, Takumi Nakagawa, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi and Clifford J Tabin

    Citation: BMC Developmental Biology 2013 13:4

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  34. Content type: Research article

    The members of the protein kinase C (PKC) family consist of serine/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKCδ, are dependent o...

    Authors: Sergio Carracedo, Ursula Braun and Michael Leitges

    Citation: BMC Developmental Biology 2013 13:2

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  35. Content type: Research article

    Members of the family Syngnathidae share a unique reproductive mode termed male pregnancy. Males carry eggs in specialised brooding structures for several weeks and release free-swimming offspring. Here we des...

    Authors: Stefan Sommer, Camilla M Whittington and Anthony B Wilson

    Citation: BMC Developmental Biology 2012 12:39

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  36. Content type: Methodology article

    Magnetic resonance imaging is a noninvasive method of evaluating embryonic development. Diffusion tensor imaging (DTI), based on the directional diffusivity of water molecules, is an established method of eval...

    Authors: Zien Zhou, Zachary DelProposto, Lianming Wu, Jianrong Xu, Jia Hua, Yan Zhou, Yongquan Ye, Zishu Zhang, Jiani Hu and E Mark Haacke

    Citation: BMC Developmental Biology 2012 12:38

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  37. Content type: Research article

    The first distinct differentiation event in mammals occurs at the blastocyst stage when totipotent blastomeres differentiate into either pluripotent inner cell mass (ICM) or multipotent trophectoderm (TE). Her...

    Authors: Manabu Ozawa, Miki Sakatani, JiQiang Yao, Savita Shanker, Fahong Yu, Rui Yamashita, Shunichi Wakabayashi, Kenta Nakai, Kyle B Dobbs, Mateus José Sudano, William G Farmerie and Peter J Hansen

    Citation: BMC Developmental Biology 2012 12:33

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  38. Content type: Research article

    Embryonic development proceeds through finely tuned reprogramming of the parental genomes to form a totipotent embryo. Cells within this embryo will then differentiate and give rise to all the tissues of a new...

    Authors: Tiphaine Aguirre-Lavin, Pierre Adenot, Amélie Bonnet-Garnier, Gaétan Lehmann, Renaud Fleurot, Claire Boulesteix, Pascale Debey and Nathalie Beaujean

    Citation: BMC Developmental Biology 2012 12:30

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  39. Content type: Research article

    During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the m...

    Authors: Zsuzsa Agoston, Naixin Li, Anja Haslinger, Andrea Wizenmann and Dorothea Schulte

    Citation: BMC Developmental Biology 2012 12:10

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  40. Content type: Research article

    Cell adhesion, an integral part of D. discoideum development, is important for morphogenesis and regulated gene expression in the multicellular context and is required to trigger cell-differentiation. G-protein l...

    Authors: Hameeda Sultana, Girish Neelakanta, Francisco Rivero, Rosemarie Blau-Wasser, Michael Schleicher and Angelika A Noegel

    Citation: BMC Developmental Biology 2012 12:3

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  41. Content type: Research article

    The desmosomal cadherins (DCs), desmocollin (Dsc) and desmoglein (Dsg), are the adhesion molecules of desmosomes, intercellular adhesive junctions of epithelia and cardiac muscle. Both the DCs and desmosomes h...

    Authors: Alexander Goonesinghe, Xing-Ming Luan, Adam Hurlstone and David Garrod

    Citation: BMC Developmental Biology 2012 12:1

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:13

  42. Content type: Research article

    Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication...

    Authors: Beata Sapetto-Rebow, Sarah C McLoughlin, Lynne C O'Shea, Olivia O'Leary, Jason R Willer, Yolanda Alvarez, Ross Collery, Jacintha O'Sullivan, Freek Van Eeden, Carmel Hensey and Breandán N Kennedy

    Citation: BMC Developmental Biology 2011 11:71

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  43. Content type: Research article

    MicroRNAs (miRNAs) are small RNA molecules that post-transcriptionally regulate gene expression and have been shown to play an important role during development. miR-1, miR-133a, miR-133b and miR-206 are expre...

    Authors: Andrie Koutsoulidou, Nikolaos P Mastroyiannopoulos, Denis Furling, James B Uney and Leonidas A Phylactou

    Citation: BMC Developmental Biology 2011 11:34

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