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Early development

Section edited by Anna-Katerina Hadjantonakis

This section considers studies in all aspects of the early development of organisms, including embryonic and somite development.

Page 1 of 2

  1. Epigenetic regulation of oocyte-specific maternal factors is essential for oocyte and early embryonic development. KPNA7 is an oocyte-specific maternal factor, which controls transportation of nuclear proteins...

    Authors: Lei Wang, Jacqelyn M. Hand, Liyuan Fu, George W. Smith and Jianbo Yao

    Citation: BMC Developmental Biology 2019 19:23

    Content type: Research article

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  2. Animals with polyploid, hybrid nuclei offer a challenge for models of gene expression and regulation during embryogenesis. To understand how such organisms proceed through development, we examined the timing a...

    Authors: Noah D. Charney, Jacob E. Kubel, Craig T. Woodard, Blanca I. Carbajal-González, Samantha Avis, Julia A. Blyth, Charles S. Eiseman, John Castorino and John H. Malone

    Citation: BMC Developmental Biology 2019 19:21

    Content type: Research article

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  3. Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to...

    Authors: Shweta Varshney, Hua-Xing Wei, Frank Batista, Mohd Nauman, Subha Sundaram, Katherine Siminovitch, Ankit Tanwar and Pamela Stanley

    Citation: BMC Developmental Biology 2019 19:19

    Content type: Research article

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  4. Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in t...

    Authors: Adriana M. Zolini, Verónica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2019 19:15

    Content type: Research article

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  5. Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate t...

    Authors: Lydia K. Wooldridge and Alan D. Ealy

    Citation: BMC Developmental Biology 2019 19:2

    Content type: Research article

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  6. BMP signaling is involved in myriad metazoan developmental processes, and study of this pathway in Drosophila has contributed greatly to our understanding of its molecular and genetic mechanisms. These studies ha...

    Authors: Scott J. Neal, Darin Dolezal, Nisveta Jusić and Francesca Pignoni

    Citation: BMC Developmental Biology 2019 19:1

    Content type: Methodology article

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  7. Integrins are transmembrane receptors that mediate cell–extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechan...

    Authors: Eiko Kawamura, Gina B. Hamilton, Ewa I. Miskiewicz and Daniel J. MacPhee

    Citation: BMC Developmental Biology 2018 18:19

    Content type: Research article

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  8. Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-...

    Authors: Paula Tríbulo, Gulnur Jumatayeva, Khoboso Lehloenya, James I. Moss, Veronica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2018 18:16

    Content type: Research article

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  9. Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite...

    Authors: Rita Alexandra Pinto, José Almeida-Santos, Raquel Lourenço and Leonor Saúde

    Citation: BMC Developmental Biology 2018 18:14

    Content type: Research article

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  10. Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome a...

    Authors: Xiaofen Hu, Li Ke, Zilong Wang and Zhijiang Zeng

    Citation: BMC Developmental Biology 2018 18:11

    Content type: Research article

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  11. Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growt...

    Authors: Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu and Jen-Her Lu

    Citation: BMC Developmental Biology 2018 18:5

    Content type: Research article

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  12. Over one third of all animal phyla utilize a mode of early embryogenesis called ‘spiral cleavage’ to divide the fertilized egg into embryonic cells with different cell fates. This mode is characterized by a se...

    Authors: Aron B. Nakama, Hsien-Chao Chou and Stephan Q. Schneider

    Citation: BMC Developmental Biology 2017 17:16

    Content type: Research article

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  13. The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fi...

    Authors: Joana Firmino, Carlos Carballo, Paula Armesto, Marco A. Campinho, Deborah M. Power and Manuel Manchado

    Citation: BMC Developmental Biology 2017 17:11

    Content type: Research article

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  14. Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. gly...

    Authors: Sita Thapa, Jayna A. Patel, Ursula Reuter-Carlson and Nathan E. Schroeder

    Citation: BMC Developmental Biology 2017 17:2

    Content type: Research article

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  15. Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Authors: Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    Citation: BMC Developmental Biology 2016 16:37

    Content type: Research article

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  16. Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    Authors: L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    Citation: BMC Developmental Biology 2016 16:36

    Content type: Research article

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  17. HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Authors: Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    Citation: BMC Developmental Biology 2016 16:31

    Content type: Research article

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  18. Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Authors: Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    Citation: BMC Developmental Biology 2016 16:19

    Content type: Research article

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  19. Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Authors: Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    Citation: BMC Developmental Biology 2016 16:10

    Content type: Research article

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  20. Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting ...

    Authors: Carolin Schille, Jens Heller and Alexandra Schambony

    Citation: BMC Developmental Biology 2016 16:1

    Content type: Research article

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  21. Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, ro...

    Authors: Jens Popken, Maik Dahlhoff, Tuna Guengoer, Eckhard Wolf and Valeri Zakhartchenko

    Citation: BMC Developmental Biology 2015 15:46

    Content type: Methodology article

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  22. The GATA-binding factor 6 (Gata6) gene encodes a zinc finger transcription factor that often functions as a key regulator of lineage specification during development. It is the earliest known marker of the primit...

    Authors: Laina Freyer, Christian Schröter, Néstor Saiz, Nadine Schrode, Sonja Nowotschin, Alfonso Martinez-Arias and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2015 15:38

    Content type: Methodology article

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  23. Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in pri...

    Authors: Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane and Hitoshi Niwa

    Citation: BMC Developmental Biology 2015 15:37

    Content type: Research article

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  24. Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro res...

    Authors: Constantinos Economou, Anestis Tsakiridis, Filip J. Wymeersch, Sabrina Gordon-Keylock, Robert E Dewhurst, Dawn Fisher, Alexander Medvinsky, Andrew JH Smith and Valerie Wilson

    Citation: BMC Developmental Biology 2015 15:35

    Content type: Research article

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  25. The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate in various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrat...

    Authors: Cheng Cui, Xiuli Ren, Dajun Liu, Xin Deng, Xin Qin, Xiangyu Zhao, Enhua Wang and Bingzhi Yu

    Citation: BMC Developmental Biology 2014 14:33

    Content type: Research article

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  26. The retinal pigmented epithelium (RPE) is a rounded shaped structure in almost all lizards. In the New World dwarf geckos, this structure shows an unusual morphology. In addition to this ocular character, we d...

    Authors: Ricardo A Guerra-Fuentes, Juan D Daza and Aaron M Bauer

    Citation: BMC Developmental Biology 2014 14:29

    Content type: Research article

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  27. Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, infl...

    Authors: VC Padmakumar, Katelyn E Masiuk, Dror Luger, Christina Lee, Vincenzo Coppola, Lino Tessarollo, Shelley B Hoover, Irina Karavanova, Andres Buonanno, R Mark Simpson and Stuart H Yuspa

    Citation: BMC Developmental Biology 2014 14:24

    Content type: Research article

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  28. The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the proc...

    Authors: Tieli Song, Tingting Wu, Fulan Wei, Ang Li, Fu Wang, Yilin Xie, Dayong Liu, Zhipeng Fan, Xuejiu Wang, Shan Cheng, Chunmei Zhang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2014 14:16

    Content type: Research article

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  29. Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growt...

    Authors: Susan M Motch Perrine, Theodore M Cole III, Neus Martínez-Abadías, Kristina Aldridge, Ethylin Wang Jabs and Joan T Richtsmeier

    Citation: BMC Developmental Biology 2014 14:8

    Content type: Research article

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  30. Important knowledge about the role of vitamin A in vertebrate heart development has been obtained using the vitamin A-deficient avian in ovo model which enables the in vivo examination of very early stages of ver...

    Authors: Inese Cakstina, Una Riekstina, Martins Boroduskis, Ilva Nakurte, Janis Ancans, Maija H Zile and Indrikis Muiznieks

    Citation: BMC Developmental Biology 2014 14:10

    Content type: Research article

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  31. Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during embryonic development. In adult mice, KLF2 regulates expression of the tight junction protein occludin, which may allow KLF2 to ...

    Authors: Aditi R Chiplunkar, Benjamin C Curtis, Gabriel L Eades, Megan S Kane, Sean J Fox, Jack L Haar and Joyce A Lloyd

    Citation: BMC Developmental Biology 2013 13:40

    Content type: Research article

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  32. Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. Since its expression is lost in several cancer types, Dab2 has been suggested to be a tumor su...

    Authors: Robert Moore, Kathy Qi Cai, Wensi Tao, Elizabeth R Smith and Xiang-Xi Xu

    Citation: BMC Developmental Biology 2013 13:39

    Content type: Research article

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  33. The myotome is the primitive skeletal muscle that forms within the embryonic metameric body wall. It can be subdivided into an epaxial and hypaxial domain. It has been shown that the formation of the epaxial m...

    Authors: Qin Pu, Aisha Abduelmula, Maryna Masyuk, Carsten Theiss, Dieter Schwandulla, Michael Hans, Ketan Patel, Beate Brand-Saberi and Ruijin Huang

    Citation: BMC Developmental Biology 2013 13:37

    Content type: Research article

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    The Erratum to this article has been published in BMC Developmental Biology 2013 13:41

  34. Velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS) is caused by a 1.5-3 Mb microdeletion of chromosome 22q11.2, frequently referred to as 22q11.2 deletion syndrome (22q11DS). This region includes TBX1, a T-...

    Authors: Laina Freyer, Sonja Nowotschin, Melinda K Pirity, Antonio Baldini and Bernice E Morrow

    Citation: BMC Developmental Biology 2013 13:33

    Content type: Methodology article

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  35. Preimplantation bovine development is emerging as an attractive experimental model, yet little is known about the mechanisms underlying trophoblast (TE)/inner cell mass (ICM) segregation in cattle. To gain an ...

    Authors: Zofia E Madeja, Jaroslaw Sosnowski, Kamila Hryniewicz, Ewelina Warzych, Piotr Pawlak, Natalia Rozwadowska, Berenika Plusa and Dorota Lechniak

    Citation: BMC Developmental Biology 2013 13:32

    Content type: Research article

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  36. Aedes aegypti is the most important global vector of dengue virus infection in humans. Availability of the draft genome sequence of this mosquito provides unique opportunities to study different aspects of its bi...

    Authors: Brent W Harker, Susanta K Behura, Becky S deBruyn, Diane D Lovin, Akio Mori, Jeanne Romero-Severson and David W Severson

    Citation: BMC Developmental Biology 2013 13:29

    Content type: Research article

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  37. Protein kinase C epsilon (PKCϵ) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKCϵ is important in different con...

    Authors: Sergio Carracedo, Ursula Braun and Michael Leitges

    Citation: BMC Developmental Biology 2013 13:16

    Content type: Research article

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  38. Live imaging provides an essential methodology for understanding complex and dynamic cell behaviors and their underlying molecular mechanisms. Genetically-encoded reporter expressing mouse strains are an impor...

    Authors: Sonja Nowotschin, Panagiotis Xenopoulos, Nadine Schrode and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2013 13:15

    Content type: Methodology article

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  39. Tenm4 is a mouse homolog of the Drosophila gene Tenascin-m (Ten-m (Odd oz)), which functions in motor neuron routing. Recently, a genome-wide association analysis for bipolar disorder identified a new susceptibil...

    Authors: Hisashi Nakamura, Rita N Cook and Monica J Justice

    Citation: BMC Developmental Biology 2013 13:9

    Content type: Research article

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  40. Individual skeletal elements of the vertebrate limbs arise through a segmentation process introducing joints in specific locations. However, the molecular pathways controlling joint formation and subsequent jo...

    Authors: Akinori Kan, Toshiyuki Ikeda, Atsushi Fukai, Takumi Nakagawa, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi and Clifford J Tabin

    Citation: BMC Developmental Biology 2013 13:4

    Content type: Research article

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  41. The members of the protein kinase C (PKC) family consist of serine/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKCδ, are dependent o...

    Authors: Sergio Carracedo, Ursula Braun and Michael Leitges

    Citation: BMC Developmental Biology 2013 13:2

    Content type: Research article

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  42. Members of the family Syngnathidae share a unique reproductive mode termed male pregnancy. Males carry eggs in specialised brooding structures for several weeks and release free-swimming offspring. Here we des...

    Authors: Stefan Sommer, Camilla M Whittington and Anthony B Wilson

    Citation: BMC Developmental Biology 2012 12:39

    Content type: Research article

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  43. Magnetic resonance imaging is a noninvasive method of evaluating embryonic development. Diffusion tensor imaging (DTI), based on the directional diffusivity of water molecules, is an established method of eval...

    Authors: Zien Zhou, Zachary DelProposto, Lianming Wu, Jianrong Xu, Jia Hua, Yan Zhou, Yongquan Ye, Zishu Zhang, Jiani Hu and E Mark Haacke

    Citation: BMC Developmental Biology 2012 12:38

    Content type: Methodology article

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