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Fig. 4 | BMC Developmental Biology

Fig. 4

From: Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis

Fig. 4

hCG-treatment induces adrenal transcripts/protein in the absence of androgen receptors. Adult hpg, hpg.SCARKO and hpg.ARKO mice were treated daily with 4 IU of hCG (or vehicle) for 1 week. a Expression of Mc2r, Cyp11b1, Akr1b7, Cyp21a1, Hao2 and Mrap was measured by qPCR and is expressed relative to Leydig cell number in each group. The presence of an asterisk (*) indicates that the effect of hCG was significant (P < 0.05) for that mouse group relative to control. b Immunohistochemical expression of CYP11B1 in testes from hpg.ARKO mice with or without treatment with hCG. Primary raw data are shown in Additional file 1

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BMC Developmental Biology

ISSN: 1471-213X

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