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Fig. 3 | BMC Developmental Biology

Fig. 3

From: Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development

Fig. 3

Phenotypic comparison of ventricular morphology in E14.5 control and conditional double and single receptor mutants. The conditional double mutants shown were newly generated for this study, but repeat a previously conducted analysis (ref. [6]). Scale bars (lower left corner of each panel) are 100 μm for low magnification panels (top row) and 50 μm for high magnification panels (middle and bottom rows). Quantitation of right and left ventricular wall thickness (mean ± SEM) is shown in the bar charts below. 8 normal embryos (from 4 litters) were used as the control. The numbers of conditional mutant embryos examined were as follows: Nkx2.5Cre/Igf1r/Insr (4 from 2 litters); Nkx2.5Cre/Igf1r (7 from 3 litters); Nkx2.5Cre/Insr (6 from 3 litters). Abbreviations: LV, left ventricle; RV, right ventricle

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BMC Developmental Biology

ISSN: 1471-213X

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