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Fig. 1 | BMC Developmental Biology

Fig. 1

From: Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila

Fig. 1

Histone H3K23A mutation affects Drosophila courtship learning. a, b Schematic presentation of Drosophila courtship learning (a) and memory (b). For learning, each male was paired with a mated female (trainer) for 1 hour. The learning index of courtship was the time spent during the final 10 min vs. the initial 10 min. For memory, each male was allowed to train for 5 hours. The memory index was calculated as the ratio of the courtship level of each trained male to the mean of sham males. An LI or MI score ≥1 indicates no learning or memory. (CI) Courtship learning and memory analysis of H3K23A, H3K4A, H3K18A, H3K37A and H3K122A overexpression flies. Histone mutant are driven by Ok107-GAL4 Courtship learning indexes (c, e, g, i, k) or memory indexes (d, f, h, j, l) were measured in various of mutant H3 overexpression flies. H3K23A overexpression flies exhibited significant difference in learning (c), and overexpressing H3K4A or H3K18A showed memory defect (f, h). Unpaired t-test was used for statistics. Error bars represent the standard error of the mean; the number of samples was indicated in the bar. n.s., not significant. *p<0.05, **p<0.01, ***p<0.001

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