Fig. 1

Immunofluorescence detection of FERMT2 (F2) in human placental tissue at week (W) 8, 13, 14, and term pregnancy. Representative images are shown. FERMT2 was continuously expressed in stem villous cytotrophoblast (CT) of floating villi throughout gestation and detected in proximal and distal extravillous trophoblast (EVT) of anchoring villi during the first and second trimester. FERMT2 was also detected in stromal mesenchyme (S) and putative developing blood vessels (BV), particularly at term pregnancy. IgG: mouse immunoglobulin used in place of primary antiserum. ST: syncytiotrophoblast. Nuclei were stained with DAPI. Scale bar = 50 μm