From: Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance
Cluster name | Pathways in cluster | Significant (FDR < 0.05) pathway expression changes |
---|---|---|
Nucleocytoplasmic transport | 38 | 24 pathways up over time in no lens & positive lens |
8 pathways up over time in no lens | ||
6 pathways up over time in positive lens | ||
Regulation of gene expression | 8 | 1 pathway down in negative & positive vs. no lens at 6Â h, & down over time in no lens |
6 pathways down in positive vs. no lens at 6Â h, & down over time in no lens | ||
1 pathway down in negative vs. no lens at 48Â h | ||
Translation | 22 | 22 pathways down over time in no lens |
Mitochondrial import | 1 | 1 pathway down over time in no lens |
rab GTPase | 1 | 1 pathway down over time in no lens |
Integration of energy metabolism | 2 | 2 pathways down over time in no lens |
Ion and vascular homeostasis | 6 | 3 pathways up over time in negative lens, & down over time in no lens |
1 pathway down in negative vs. positive lens at 6Â h & 48Â h | ||
2 pathways down in negative vs. positive lens at 6Â h | ||
Signal transduction | 3 | 1 pathway up over time in negative lens |
2 pathways down over time in no lens | ||
Solute transport | 2 | 1 pathway down over time in no lens |
1 pathway up in positive vs. no lens at 48Â h |