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Fig. 2 | BMC Developmental Biology

Fig. 2

From: Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance

Fig. 2

Pathway enrichment in the regulation of gene expression cluster. a Bubble plot illustrating the NES and FDR across all pairwise comparisons for the eight enriched pathways in the ‘regulation of gene expression’ cluster. Statistically significant enrichments (FDR < 0.05) are shown as filled circles. b Heat map showing the mean LFQ intensity across lens conditions for all LES proteins contributing to the enrichment of one or more pathways in the cluster. Note that, because the ‘cellular senescence’ pathway was significantly enriched across multiple pairwise comparisons, the LES varied depending on the comparison being made. Full details of the LES for each comparison are provided in, Additional file 4 Figure S4

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