Gene symbol/ | Gene name | Species/ NCBI reference | Gene function (Gene atlas) | Biological process | Reference (Function) | % of identity with human protein sequence | % of identity with quail genomic sequencea |
---|---|---|---|---|---|---|---|
ESR1 | estrogen receptor 1 | G. gallus 396,099 | Encodes the protein estrogen receptor alpha, plays role in the sex differentiation of reproductive tract, regulates the expression of oviduct genes | 4A- nuclear receptor; transcription regulator; binding estradiol, epithelial cell development, cell differentiation | 79 | 99 | |
C. japonica 107,311,566 | Transcription regulator; binding estradiol, epithelial cell development, cell differentiation | [40] | n/a | ||||
OVAL | Ovalbumin-SERPINB14 | G. gallus 396,058 | Encodes ovalbumin in Ov-serpin family, located in extracellular space | Oviduct secretome, binds calcium, responds to steroid hormones, constitutes egg white | [41] | 41 | 93 |
C. japonica 107,309,565 | Oviduct secretome, constitutes egg white, responds to steroid hormones | [42] | n/a | ||||
OVM | SPINK7- serine peptidase inhibitor, Kazal type 7 | G. gallus 416,236 | Encodes ovomucoid protein to the extracellular space, responds to steroid hormones, binds IgE, IgG | Secreted as egg white protein, allergenic as a food component, responsive to steroid hormones (progesterone), allergenic component of an egg white | 44 | 96 | |
C. japonica 107,320,484 | n/a | ||||||
KRT5 | keratin 5 | 407,779 | Encodes protein keratin 5, type II cytoskeletal 5 | Interacts with KRT14 to form cytoskeleton of basal epithelium, expressed in stem cells of fallopian tube, epithelial differentiation | [15] | 80b | 98 |
KRT14 | keratin, type I cytoskeletal 14 | 408,039 | Marker of the stratified epithelium as keratin filament | Interacts with KRT5 to form the cytoskeleton of basal epithelium, expressed in tumor cells of fallopian tube, marker of chicken keratinocytes, epithelial differentiation | [26] | 69 | 100 |
OCLN | occludin | G. gallus 396,026 | Encodes protein occludin, marker of tight junctions in epithelial cells | Component of plasma membrane, role in cellular binding, forms tight junctions | [26] | 47 | 96 |
C. japonica 107,325,447 | n/a | ||||||
CD44 | cell surface glycoprotein CD44 | G. gallus 395,666 | Encodes CD44 antigen, marker of epithelial stem cells in fallopian tube | Role in cell adhesion (cell to cell) and postponement of the apoptotic process | [15] | 48 | 100 |
C. japonica 107,314,385 | n/a | ||||||
LGR5 | Leucine-rich repeat containing G protein-coupled receptor 5 | G. gallus 427,867 | Encodes protein LGR5, induced by Wnt/β-Catenin signaling | Marker of stem cells in the ovary and tubal epithelia | [14] | 30c | 99 |
C. japonica 107,310,333 | n/a | ||||||
MSI-1 | Musashi-1; Musashi RNA binding protein- 1 | G. gallus 416,979 | Marker of epithelial early lineage, marker of stem cells in human endometrium | Maintains proliferation and multipotent potential of epithelial cells (emerging from Müllerian duct) | [45] | 80 | 100 |
C. japonica 107,321,418 | [31] | n/a | |||||
NANOG | Nanog homebox | G. gallus 100,272,166 | Encodes transcriptional factor of pluripotency: homebox protein NANOG, Marker of stem cells in ovarian epithelium | Maintains stem cell population, chicken stem cell marker | [32] | 89 | 100 |
C. japonica 107,318,297 | [46] | n/a | |||||
OCT4/ cPOUV | POU domain class 5 transcription factor 3, Octamer-binding protein 4 | 427,781 | Encodes transcription factor POU5F3 | Maintains cell pluripotency, maintains population of somatic stem cells, shows responses to wounding | [33] | 43 | 97 |
SOX9 | SRY sex determining region Y-box 9 | G. gallus 374,148 | Encodes HMG box transcription factor, marker of epithelial early lineage, transcription epithelial-mesenchymal transition marker | Negatively regulates the differentiation of epithelial cells, maintains the population of somatic stem cells, plays role in transdifferentiation; regulation of cell adhesion, activated during chondrogenesis in chicken | [28] | 99 | 100 |
C. japonica 107,322,214 | [29] | n/a |