Fig. 2

Epigenetic and expression profiles for 31 distinct clusters and their characterisation. a Hierarchical clustering of the profiles of H3K27me3 (peaks), H3K4me3 (peaks), RNAPII (peaks) and expression signal (reads per million) across 117,438 distinct gene promoter-cell type pairs. 31 clusters of distinct signatures were detected. b Average number of peaks /Average RNA-seq signal at representative clusters from 31 clusters, displaying divergent epigenetic and transcription profiles. c Under and over-representation of cell types in each cluster (significance was assessed with hypergeometric test). d Under and over-representation of gene types per cluster (significance was assessed with hypergeometric test)