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Table 1 Results of microarray analysis of tbx5 knockdown zebrafish embryos

From: Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos

GenBank Accession

Gene Symbol

Gene Name

Biological Process

Stages

Reference

Up-regulated genes a

 NM_131188

mylz2

myosin, light polypeptide 2, skeletal muscle

phosphorylation

24

Xu Y, et al. 2010

 NM_178436

mcm5

MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)

cell cycle, apoptosis

30

Soojin Ryu, et al. 2005

 NM_130925

khdrbs1

KH domain containing, RNA binding, signal transduction associated 1

cell cycle, phosphorylation

24,30

Paronetto MP, et al. 2011

 NM_130926

nme2

non-metastatic cells 2, protein (NM23B) expressed in

cell cycle, phosphorylation

30,48

Prakash T, et al. 2010

 NM_131404

pcna

proliferating cell nuclear antigen

cell cycle

24,30,48

Sapna D B, et al. 2010

 NM_200650

prmt1

protein arginine methyltransferase 1

cell cycle, apoptosis

24,30,48

A. Scoumanne, et al. 2009

S ribosomal proteins

 NM_201153

rps3

ribosomal protein S3

cell cycle, apoptosis

24,30,48

Sang Bae Lee, et al. 2010

 NM_214793

rps8

ribosomal protein S8

apoptosis

30

Hao Y, et al. 2011

 NM_200750

rps19

ribosomal protein S19

cell cycle, apoptosis,

24,30,48

K. Miyake, et al.2008

L ribosomal proteins

 NM_001003844

rpl6

ribosomal protein L6

cell cycle

30,48

Wu Q, Gou Y, Wang Q, Jin H, Cui L, et al. 2011

 NM_213644

rpl7

ribosomal protein L7

cardiac myogenesis, cell cycle, apoptosis

24,30,48

Neumann F, et al. 1995

 NM_212784

rpl13a

ribosomal protein L13a

apoptosis

24,30,48

Hu, B., et al. 2009

 NM_213107

rpl4

ribosomal protein L4

cardiac myogenesis, apoptosis

24,30,48

Zhu, H, et al. 2007

Down-regulated genes a

 NM_001001832

ift57

intraflagellar transport protein 57

apoptosis

30,48

Sarmah B., et al. 2007

 NM_001020710

pskh1

protein serine kinase H1

phosphorylation

30,48

Brede G., et al. 2003

 NM_001003738

ciapin1

cytokine induced apoptosis inhibitor 1

cell cycle, apoptosis

30,48

Li X, Hao Z, Fan R, et al. 2007

 NM_001077567

eif2ak1

eukaryotic translation initiation factor 2-alpha kinase 1

phosphorylation

30,48

Rothenburg S, et al. 2005

 NM_001013443

eif4g2b

eukaryotic translation initiation factor 4, gamma 2b

apoptosis

30,48

Nousch, M., Reed, V., et al. 2007

 NM_001030253

bcl2

B-cell leukemia/lymphoma 2

apoptosis

30,48

Kratz, E., et al. 2006

 NM_131837

cebp1

CCAAT/enhancer binding protein (C/EBP) 1

cell cycle

30,48

Kitaguchi, T., et al. 2009

 NM_199784

eapp

e2f-associated phosphoprotein

apoptosis

30,48

Novy M., et al. 2005

 NM_001102387

nox1

NADPH oxidase 1

cardiac myogenesis

30,48

Jian Li, et al. 2006

 NM_182885

pcdh10b

protocadherin 10b

cell cycle

30,48

Murakami, T., et al. 2006

 NM_200348

cdc73

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

cardiac myogenesis, cell cycle

30,48

Bai, X., et al. 2004

 NM_173236

hdac1

histone deacetylase 1

cell cycle, apoptosis

24,48

Burns, C.E., et al. 2009

 NM_199481

ccng1

cyclin G1

cell cycle

24,48

Newman, M., et al. 2009

 NM_001002198

btbd9

BTB (POZ) domain containing 9

cell cycle

24,30,48

Schormair B, et al. 2011

 NM_001079826

bida

BH3 interacting domain death agonist

apoptosis

24,30,48

Kratz, E., et al. 2006

 NM_001039634

wt1b

Wilms tumor 1b

apoptosis

24,30,48

Perner B, et al. 2007

 NM_198146

akt2

v-akt murine thymoma viral oncogene homolog 2

apoptosis, phosphorylation

24,30,48

Jensen, P.J., et al. 2010

 NM_131390

gsk3a

glycogen synthase kinase 3 alpha

cardiac mophogenesis

24,30,48

Lee, H.C., et al. 2007

  1. aThe expression of genes in the WT group was taken as the reference of 1. If the expression of a gene in the MO group and in the MOIGF1 group were both higher than 1.5 folds of that in the WT group, the gene would be marked as “up-regulation”. Conversely, if the expression of a gene in the MO group and in the MOIGF1 group were both lower than 1.5 folds of that in the WT group, the gene would be marked as “down-regulation”