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Fig. 8 | BMC Developmental Biology

Fig. 8

From: In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms

Fig. 8

Tears in the basement membrane cause an abrupt shift from lamellipodia-dependent cell crawling to purse string mediated wound closure. a-h Wound healing in an intact animal with a torn basement membrane (BM). Arrows indicate the region where the basement membrane has torn, exposing the mesoglea (M)(a-f). Lamellipodia (arrowheads) are apparent as epithelial cells (Ep) move across the BM (a-e), but disappear when cells reach the torn area (f). The remaining wound is closed by a classic purse string mechanism (g, h). Experiment was replicated >10 times. Scale bar = 50 μm

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BMC Developmental Biology

ISSN: 1471-213X

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