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Fig. 7 | BMC Developmental Biology

Fig. 7

From: In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms

Fig. 7

Wounds can close using a classic purse string mechanism. a-c Time lapse images of a wound closing without lamellipodia. There are small moving projections at the wound periphery, as well as clear contractions in marginal cells that precede gap closure. Marginal cells (blue) undergo major shape changes, while cells one to two tiers back (pink) do not (see Additional file 11 for timelapse movie). d,e Phalloidin staining of closing (d) and recently closed (e) wounds similar to those shown in a-c reveals actin accumulation at the circumference. f-h Wound of similar size and shape to (a-c) closing with lamellipodia (e.g. indicated by arrowheads). Contractions are only present after gap closure, as in the wounds in Figs. 2 and 3. See Additional file 12 for timelapse movie. Experiment was replicated >10 times. Scale bar = 50 μm

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