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Fig. 7 | BMC Developmental Biology

Fig. 7

From: The asymmetric cell division machinery in the spiral-cleaving egg and embryo of the marine annelid Platynereis dumerilii

Fig. 7

Maternally provided cell adhesion related complexes. (a-d) Transcriptional profiles of components for various cell adhesion related complexes during early development of P. dumerilii based on RNA-seq: x-axis shows time in hours post fertilization (hpf), y-axis shows median level of transcripts in fragments per kilobase per million reads (FPKM) (Additional file 5). a Expression profiles for components of cadherin-mediated cell-cell adhesion complex. Echinoid and afadin exhibit high levels of transcripts at 2 hpf. n-cadherin shows slightly elevated levels of expression at 2 hpf compared with later time points. b Expression profiles for selected components of the planar cell polarity (PCP) pathway. Four-jointed is an intracellular kinase that regulates Fat and Dachsous through phosphorylation. Transcripts for extracellular domain proteins Vangl, Fat, Dachsous, and Celsr1/Flamingo exhibit high levels of expression at 2 hpf, whereas levels for four-jointed shows early zygotic expression beginning around 4 hpf and peaking at 6 hpf. c, d Expression profiles for components with previously described functions in neural cell recognition. Latrophilin 1 and its binding partner Teneurin translate polarity cues to internal signaling cascades, whereas Neuroglian and Contactin mediate cell-surface polarities at the juxtanodal region of Nodes of Ranvier in myelinated neurons. c Components for each complex exhibit high maternal contribution and similar developmental expression profiles in P. dumerilii. At synaptic connections, Neuroligin binds Magi2 intracellularly and is asymmetrically in postsynaptic neurons. Also, the protocadherin Pcd11x negatively regulates dendritic branching in neurons. d All three genes are expressed at high levels at 2 hpf relative to later time points in P. dumerilii. For error bars see Additional file 12

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