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Fig. 4 | BMC Developmental Biology

Fig. 4

From: Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

Fig. 4

Cardiovascular anomalies in the 15.5dpc embryos with the Mesp1Cre-driven deletion of Pcsk5. (a) Three-dimensional reconstruction of a control (Pcsk5 wt/flox ; Mesp1Cre) heart. Left and right ventricles (LV, RV) are separated by ventricular septum (VS); the aorta (Ao) arises from the left ventricle and forms the arch on the left side of the trachea (Tr). Pulmonary artery (PA) leaves from the right ventricle. (a’, a”) Corresponding views of the two representative abnormal hearts (Psck5 Δ1/flox ; Mesp1Cre). (a’) Transposition of great arteries: aorta arises from the right, and pulmonary artery – from the left ventricle. (a”) Ventricular septal defect (VSD) and double outlet right ventricle (DORV): both great arteries arise from the right ventricle. (b) MRI section through the control heart. The mitral valve (MV) is formed between the left ventricle (LV) and the left atrium (LA). Atrial septum (AS) separates left and right atria (RA, LA). (b’) Corresponding sections through the heart of the Psck5 Δ1/flox ; Mesp1Cre embryo, showing abnormally formed, thickened atrioventricular valves (AVV) and atrial septal defect (ASD). Left superior vena cava (LSVC) is indicated in both sections. All scale bars = 0.5 mm

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