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Fig. 1 | BMC Developmental Biology

Fig. 1

From: Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development

Fig. 1

Loss of Grhl3 leads to premature suture fusion and aberrant skull morphology in E18.5 mouse embryos. a-d Dissecting light microscopy images showing shortened and flattened skull morphology, lack of suture vascularisation and decreased skull size in Grhl3 −/− embryos (b, d) compared to WT (a, c) at E18.5. a, b shown in lateral view, C-D in dorsal view. e-h Alcian Blue/Alizarin red staining of WT (e, g) and Grhl3 −/− (f, h) embryos in lateral (e, f) and dorsal (g, h) views, highlighting skull morphology and suture development. i, j High-powered images of the boxed region in (g, h), showing a clearly open suture in WT embryos (i), and a fused suture in Grhl3 −/− embryos (j)

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BMC Developmental Biology

ISSN: 1471-213X

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