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Fig. 5 | BMC Developmental Biology

Fig. 5

From: BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Fig. 5

Spatio-temporal changes in BRE::gfp transcriptional activity in blood and lymphatic vessels. a–c Transverse sections at the level of the neck of E10.5 (a), E12.5 (b) and E14.5 (c) BRE::gfp embryos with immunodetection of GFP, the blood vessel marker Endomucin and the lymphatic vessel marker PROX1. DAPI is used to stain nuclei. Boxed areas are enlarged in the right panels, with single GFP, Endomucin and PROX1 staining next to it. Skin biopsies of E14.5 (d) and E16.5 (e) BRE::gfp embryos with immunodetection of GFP, Endomucin and PROX1. Boxed areas are shown in the middle (and right) panels with single staining for GFP in the right panel. CV: cardinal vein; DA: dorsal aorta; LS: lymphatic sac. Scale bars: 75 μm (d–e, left panels); 50 μm (a–c, left panels; d–e, right panels); 25 μm (a–c, right panels)

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BMC Developmental Biology

ISSN: 1471-213X

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