Fig. 1

Spatial expression of Xenopus laevis hace1 in early development. Expression of hace1 during Xenopus laevis development was analyzed by whole-mount in situ hybridization using an antisense probe (upper panels) and sense probe as a control (lower panels). a, b At stage 4 (a) and 11 (b), hace1 was expressed throughout the presumptive ectoderm. c At stage 15, hace1 expression was weakly detected at the dorsal ectoderm. d At stage 23, hace1 was expressed in the neural tissue and also showed spotty expression in the epidermis. The rightmost panel shows a magnification of the red boxed region. e hace1 was expressed in the brain, eye, neural tube, branchial arch, ear vesicle, and kidney at stage 31. The right panel shows a magnified view of the embryo. Animal is to the top in lateral views (a, b). Dorsal is to the top in lateral or anterior views (c, d, e). Anterior is to the left in dorsal or lateral views (c, d, e)